Modelling Laminin mediated adhesion and congenital muscular dystrophy in Zebrafish

斑马鱼层粘连蛋白介导的粘附和先天性肌营养不良症建模

• 批准号: nhmrc : 1045467
• 负责人: Prof Peter Currie
• 金额: $ 39.08万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/modelling-laminin-mediated-dystrophy-zebrafish/111753
• 关键词: Modelling; Laminin; mediated; adhesion; congenital

Congenital Muscular Dystrophy (CMD) is a muscle wasting conditions arising from mutations in the Lamina alpha 2 gene (lama2) gene. We have established zebrafish as a model system in which to determine the mechanistic basis of CMD pathology. We have isolated mutations in the zebrafish Lama2 gene and have determined that Lama2-deficient zebrafish accurately model the human condition. We aim to use the advantages of the zebrafish system to model treatments for muscular dystrophy

先天性肌营养不良(CMD)是由肌层α2基因(Lama2)基因突变引起的肌肉萎缩。我们已经建立了斑马鱼作为一个模型系统，在其中确定CMD的病理机制基础。我们已经分离了斑马鱼Lama2基因的突变，并确定Lama2缺失的斑马鱼准确地模拟了人类的情况。我们的目标是利用斑马鱼系统的优势来模拟肌肉营养不良的治疗方法。