How limbs evolved from fins: the role of somite cells

四肢如何从鳍进化而来：体细胞的作用

• 批准号: DP190102204
• 负责人: Prof Peter Currie
• 金额: $ 26.67万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190102204
• 关键词: How; limbs; evolved; fins; role

This project aims to investigate the developmental basis of vertebrate appendage diversity and how during evolution limbs became fins. The project expects to determine how specific populations of cells that regulate fin formation arise during development, the genetic basis of their function, and how their role in development has evolved in lineages with divergent appendage anatomy. Expected outcomes include understanding the molecular basis of the fin-limb transition and the origin of divergent appendage patterning systems. This should provide significant benefits by advancing our knowledge of the relationship between evolution and development, and understanding limb defects, which are amongst the most common of human congenital malformations.

本研究旨在探讨脊椎动物附肢多样性的发育基础，以及肢体在进化过程中如何演变为鳍。该项目希望确定在发育过程中调节鳍形成的特定细胞群是如何产生的，它们功能的遗传基础，以及它们在发育中的作用如何在具有不同附属物解剖结构的谱系中演变。预期成果包括了解鳍肢过渡的分子基础和分歧的附属物图案系统的起源。这将通过推进我们对进化与发育之间关系的认识，以及了解肢体缺陷（这是人类先天性畸形中最常见的），提供显着的益处。