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How limbs evolved from fins: the role of somite cells

How limbs evolved from fins: the role of somite cells
四肢如何从鳍进化而来：体细胞的作用
批准号：
DP190102204
负责人：
Prof Peter Currie
金额：
$26.67万
依托单位：
Monash University
依托单位国家：
澳大利亚
项目类别：
Discovery Projects
财政年份：
2019
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2019-01-01 至 2021-12-31
来源：
https://dataportal.arc.gov.au/RGS/Web/Grants/DP190102204
关键词：
Howlimbsevolvedfinsrole

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英文摘要
This project aims to investigate the developmental basis of vertebrate appendage diversity and how during evolution limbs became fins. The project expects to determine how specific populations of cells that regulate fin formation arise during development, the genetic basis of their function, and how their role in development has evolved in lineages with divergent appendage anatomy. Expected outcomes include understanding the molecular basis of the fin-limb transition and the origin of divergent appendage patterning systems. This should provide significant benefits by advancing our knowledge of the relationship between evolution and development, and understanding limb defects, which are amongst the most common of human congenital malformations.
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