Defining the molecular regulation of muscle stem cell action during organ growth

定义器官生长过程中肌肉干细胞作用的分子调节

• 批准号: nhmrc : 1139253
• 负责人: Prof Peter Currie
• 金额: $ 49.92万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-molecular-regulation-organ-growth/1318951
• 关键词: Defining; molecular; regulation; muscle; stem

How do organs grow to develop a complex cellular structure. Organ growth needs a careful balance between cell commitment and stem cell self renewal to maintain tissue growth trajectories. How this balance is achieved at the cellular and molecular level remains unresolved for most organ systems. This application studies a specific stem cell pool within the zebrafish myotome and how it is used to drive organ growth.

器官如何发展以发展复杂的细胞结构。器官生长需要在细胞承诺和干细胞自我更新之间保持仔细的平衡，以维持组织生长轨迹。对于大多数器官系统，在细胞和分子水平上如何达到这种平衡仍未解决。该应用研究斑马鱼肌病中的特定干细胞池以及如何用于驱动器官生长。