权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Studies on the dynamics of ultra-trace elements in the body

体内超微量元素动态研究

基本信息

批准号：
04557028
负责人：
SAITO Kazuo
金额：
$ 9.47万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1994
项目状态：
已结题

项目摘要

In the present study, we intended to evaluate the distributions and functional roles of ultra-trace elements in the body from analytical and biochemical investigations.Results obtained in the present investigations are as follows ; 1)We established the simultaneous multi-analytical procedure to determine the ultra-trace elements by ICP-MS spectrometry in biological samples. 2)Ultra-trace and trace elements were measured in 5 regions of human brains. Significant negative correlations between age and K or Rb and significant positive correlations between age and Cd or Sn were found in most regions of the human brain. Significant decreases in Rb concentrations by aging were also observed in 7 regions of the rat brain. 3)Ultra-trace and trace elements concentrations were determined in cancerous tissues in patients with stomach cancer. Significant decreases in Cd and Sr concentrations and increases in Cu and Ti concentrations were observed in cancerous stomach tissues as compared to those in … More noncancerous stomach tissues. 4)Changes in Cu, Zu, Mn and Mo concentrations in 7 regions of the rat brain and release of Zn from the rat hippocampus were determined after various durations of restraint stress and after release from restraint stress.Cu and Zu concentrations decreased in 3 regions by restraint stress and did not return to the controllevels 2 hour after release from restraint stress. Mn and Mo concentrations decreased depending on the duration of the restrain stress and returned to the control levels 2 hour after release from restraint stress. Zn was released from hippocampus tissues by short periods of restraint stress. 5)Ultra-trace and trace elements in plasma and the organs were determined in rats exposed silica dust. Cu concentrations in plasma and in the lung increased depending on dose and time after exposure to silica dust. Zn concentrations both in plasma and in the lung decreased after exposure to silica dust. These results suggest that Cu may be a promising, accurate and sensitive index of lung injury in silicoticrats and/or in human exposed to silica dust in the workplace. The plasma Zn level may serve as a supplementary index of lung damage. Less

在本研究中，我们打算从分析和生化调查来评估超微量元素在体内的分布和功能作用。目前的调查结果如下：1)建立了用ICP-MS法同时测定生物样品中微量元素的多组分分析方法。2)测定了人体大脑5个区域的微量元素和超微量元素。年龄与K或Rb呈显著负相关，而年龄与Cd或Sn呈显著正相关。随着年龄的增长，大鼠大脑的7个区域Rb浓度也显著下降。3)测定胃癌患者癌变组织中微量元素和超微量元素浓度。与非癌性胃组织相比，癌性胃组织中Cd和Sr浓度显著降低，Cu和Ti浓度显著升高。4)测定不同约束应激持续时间和解除约束应激后大鼠脑7个区域Cu、Zu、Mn、Mo浓度的变化及海马Zn的释放量。Cu和Zu浓度在3个区域均因抑制应激而下降，且在释放抑制应激2 h后未恢复到对照水平。Mn和Mo浓度随抑制应力持续时间的长短而下降，并在抑制应力解除后2小时恢复到对照水平。在短时间的约束应激下，海马组织释放Zn。5)测定了接触硅尘大鼠血浆和脏器中的超微量和微量元素含量。暴露于硅尘后，血浆和肺中的铜浓度随剂量和时间的增加而增加。暴露于硅尘后，血浆和肺中的锌浓度均下降。这些结果表明，铜可能是一个有希望的、准确和敏感的指标，用于矽肺大鼠和/或工作场所暴露于二氧化硅粉尘的人的肺损伤。血浆锌水平可作为肺损伤的补充指标。少