Development of hereditary hyperlipidemic rabbit related to evolution of myocardial infarction

家兔遗传性高脂血症的发生发展与心肌梗死的演变有关

• 批准号: 05557038
• 负责人: TOMOIKE Hitonobu
• 金额: $ 8.32万
• 依托单位: Yamagata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05557038/
• 关键词: myocardial infarction; hyperlipidemia; WHHL rabbit; triglyceride; 遺伝性高脂血症家兎; 高コレステロール血症; 高トリグリセリド血症; 血管造影

1.Genetically pure-bred animal model for evolution of myocardial infarction. The Watanabe-heritable hyperlipidemic (WHHL) rabbit is a strain of Japanease rabbit which is characterized by grossly elevated levels of serm cholesterol and triglyceides.During serial inbreeding of off-spring from WHHL line, we noted a wide variation of the level of serm triglycerides.Accordingly, we tried to determine the characteristics of the gene, related to the level of serm triglycerides.We also examined pathologically whether the level of triglycerides determines the severity of aortic and coronary atherosclerosis.Development an animal model of myocardial infarction looks feasible.2.Precise analysis of the presence and severity of atherosclerosis in minute vasculature along the WHHL rabbit's coronary artery.We installed a soft X-ray system to document lesions of atherosclerosis from the artery to arteriole.We found that the coronary atherosclerotic lesions in WHHL invariably limited to the proximal portion of both the right and left coronary arteries.

1.心肌梗死演变的基因纯种动物模型。渡边遗传性高脂血症(WHHL)兔是一种以血清胆固醇和甘油三酯水平显著升高为特征的日本兔品系。在WHHL系后代的连续近亲交配过程中，我们注意到血清甘油三酯水平的广泛变异。我们还从病理角度分析了甘油三酯水平是否决定了动脉和冠状动脉粥样硬化的严重程度。建立心肌梗死动物模型似乎是可行的。2.对WHHL兔冠状动脉沿线微小血管中动脉粥样硬化的存在和严重程度进行了精确的分析。我们安装了软X射线系统来记录从动脉到小动脉的动脉粥样硬化病变。我们发现WHHL的冠状动脉粥样硬化病变总是局限于右冠状动脉和左冠状动脉的近端。

项目成果

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Noma M 等人：“重复性短暂冠状动脉闭塞引起的侧支循环发育与先前存在的侧支循环的功能状态有关。”

Ando H,et al.: "Assessment of preload reserve in myocardial ischemia : The relation between preload reserve and ischemic size differs between anterior descending and circumflex coronary artery occlusion in a canine model." Jpn Circ J. 57. 1111-1119 (1993)

Ando H 等人：“心肌缺血中前负荷储备的评估：在犬模型中，前降支和回旋冠状动脉闭塞之间的前负荷储备与缺血大小之间的关系有所不同。”

Tomoike H :: Collateral Circulation. Kluwer Academic Publishers, (149-172), 283 (1993)

Tomoike H:: 侧支循环。

Endo T, et al.: "Relation of principal components of ECG maps to loci of wall motion abnormality in old myocardial infarction." Am J Physiol. 266. 1604-1609 (1994)

Endo T 等人：“心电图主要成分与陈旧性心肌梗塞中室壁运动异常位点的关系。”

Takeishi Y,et al.: "Adenosine-induced heterogeneous perfusion accompanies myocardial ischemia in the presence of advanced coronary disease." Am Heart J. 127. (1994)

Takeishi Y 等人：“在晚期冠心病的情况下，腺苷诱导的异质灌注会伴随心肌缺血。”