SERUM CHOLESTEROL VALUES OF THE NIH WHHL RABBIT

研究服务司兽医资源处 渡边高脂兔(WHHL)繁育群体的建立 作为调查人员的资源，需要使用 这个动物模型。这个菌落的特征是血清 总胆固醇，脂蛋白各组份的胆固醇水平 和血清甘油三酯水平。血液被采集自 以下年龄的兔子：六周、三个月、七岁 几个月，一年。血清总胆固醇值范围为 310~1251 mg/dl，平均828 mg/dl。低密度 脂蛋白(LDL)胆固醇值在1185毫克/分升之间 平均值为630毫克/分升。因此，总胆固醇的80%是由 低密度脂蛋白的含量。从885人大幅下降到 8岁儿童血清总胆固醇为576 mg/dl 几周和一年。最显著的下降发生在 年龄在15到25周之间。总体上没有差别。 因性行为而导致的胆固醇浓度。血清甘油三酯 平均值为394 mg/dl，最低为107 mg/dl，最低为959 mg/dl。 甘油三酯浓度最初是从 367至565毫克/分升，在两个月至三个月龄之间。 然而，血清甘油三酯浓度下降到349 Mg/dl在一岁内。血清甘油三酯浓度 受到了兔子性别的影响。卑鄙的男性和女性 血清甘油三酯浓度分别为510 mg/dl和309 mg/dl 分别

The Veterinary Resources Branch, Division of Research Services established a Watanabe Hyperlipidemic Rabbit (WHHL) breeding colony to be used as a resource for investigators requiring the use of this animal model. The colony is being characterized for serum total cholesterol, cholesterol levels of the lipoprotein fractions and serum triglyceride levels. Blood is being collected from rabbits at the following ages: six weeks, three months, seven months, and one year. Total serum cholesterol values ranged from 310 to 1251 mg/dl with a mean of 828 mg/dl. The low density lipoprotein (LDL) cholesterol values ranges from 1185 mg/dl with a mean of 630 mg/dl. Thus 80% of the total cholesterol was compose of LDL cholesterol. There was a substantial decrease from 885 to 576 mg/dl in serum total cholesterol between the ages of eight weeks and one year. The most significant decrease occurred between the ages of 15 to 25 weeks. There was no difference in total cholesterol concentrations due to sex. The serum triglyceride values ranged from 107 to 959 mg/dl with a mean of 394 mg/dl. There was an initial increase in triglyceride concentration from 367 to 565 mg/dl between two months and three months of age. However, the serum triglyceride concentration decreased to 349 mg/dl within one year of age. The serum triglyceride concentration was influenced be the sex of the rabbit. The mean male and female serum triglyceride concentrations were 510 mg/dl and 309 mg/dl respectively