SERUM CHOLESTEROL VALUES OF THE NIH WHHL RABBIT

NIH WHHL 兔的血清胆固醇值

• 批准号: 3916161
• 负责人: D BARNARD
• 金额: --
• 依托单位: DIVISION OF RESEARCH SERVICES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3916161
• 关键词: animal colony; cholesterol; disease /disorder model; familial hyperlipoproteinemia; gender difference; hyperlipidemia; laboratory rabbit; low density lipoprotein; triglycerides; veterinary medicine

The Veterinary Resources Branch, Division of Research Services established a Watanbe Hyperlipidemic Rabbit (WHHL) breeding colony to be used as a resource for investigators requiring the use of this animal model. The colony is being characterized for serum triglyceride levels. Blood is being collected from rabbits at the following ages: six weeks, three months, seven months, and one year. Total serum cholesterol values ranged from 310 to 1251 mg/dl with a mean of 828 mg/dl. The low density lipoprotein (LDL) cholesterol values ranges from 1185 mg/dl with a mean of 630 mg/dl. Thus 80% of the total cholesterol was composed of LDL cholesterol. There was a substantial decrease from 885 to 576 mg/dl in serum total cholesterol between the ages of eight weeks and one year. The most significant-decrease occurred between the ages of 15 to 25 weeks. There was no difference in total cholesterol concentrations due to sex. The serum triglyceride values ranged from 107 to 959 mg/dl within one year of age. The serum triglyceride concentration decreased to 349 mg/dl within one year of age. The serum triglyceride concentration was influenced by the sex of the rabbit. The mean male and female serum triglyceride concentrations were 510 mg/dl and 309 mg/dl respectively.

兽医资源分支，研究服务司成立 Watanbe高脂血症兔（WHHL）繁殖群，用作 需要使用该动物模型的研究者的资源。 的 对菌落进行血清甘油三酯水平表征。 血液 从以下年龄的兔子中收集：六周，三周， 七个月，七个月，一年。 血清总胆固醇值范围 从310到1251 mg/dl，平均值为828 mg/dl。 低密度 脂蛋白（LDL）胆固醇值范围为1185 mg/dl，平均值为 630毫克/分升。 因此，总胆固醇的80%由LDL组成 胆固醇 有一个大幅度下降，从885至576毫克/分升， 血清总胆固醇在8周龄和1岁之间。 的 最显著的下降发生在15至25周龄之间。 总胆固醇浓度不存在性别差异。 一年内血清甘油三酯值范围为107 ~ 959 mg/dl 年龄。 血清甘油三酯浓度下降至349 mg/dl， 一岁。 血清甘油三酯浓度的影响， 兔子的性别 雄性和雌性血清甘油三酯平均值 浓度分别为510 mg/dl和309 mg/dl。