SERUM CHOLESTEROL VALUES OF THE NIH WHHL RABBIT

研究服务处兽医资源分支 建立了渡边高脂血症兔（WHHL）育种 殖民地被用作需要使用的调查人员的资源， 这个动物模型。 正在对殖民地进行血清鉴定 总胆固醇、脂蛋白组分的胆固醇水平 和血清甘油三酯水平。 血液正在收集， 以下年龄的家兔：6周龄、3月龄、7月龄 几个月，一年。 血清总胆固醇值范围 从310到1251 mg/dl，平均值为828 mg/dl。 低 密度脂蛋白（LDL）胆固醇值范围从1185 mg/dl，平均值为630 mg/dl。 占总数的80% 胆固醇由LDL胆固醇组成。 有一个 血清总浓度从885 mg/dl大幅降至576 mg/dl 胆固醇在八周到一岁之间。 的 最显著的下降发生在15至25岁之间 周 总胆固醇没有差异 由于性的浓度。 血清甘油三酯值范围为 从107到959 mg/dl，平均值为394 mg/dl。 有一个 甘油三酯浓度从367初始升高至565 在两个月和三个月之间的年龄。 然而，在这方面， 血清甘油三酯浓度降至349 mg/dl 在一岁以内。 血清甘油三酯浓度为 受兔子性别的影响。 平均男性和女性 血清甘油三酯浓度分别为510 mg/dl和309 mg/dl 分别

The Veterinary Resources Branch, Division of Research Services established a Watanabe Hyperlipidemic Rabbit (WHHL) breeding colony to be used as a resource for investigators requiring the use of this animal model. The colony is being characterized for serum total cholesterol, cholesterol levels of the lipoprotein fractions and serum triglyceride levels. Blood is being collected from rabbits at the following ages: six weeks, three months, seven months, and one year. Total serum cholesterol values ranged from 310 to 1251 mg/dl with a mean of 828 mg/dl. The low density lipoprotein (LDL) cholesterol values ranges from 1185 mg/dl with a mean of 630 mg/dl. Thus 80% of the total cholesterol was composed of LDL cholesterol. There was a substantial decrease from 885 to 576 mg/dl in serum total cholesterol between the ages of eight weeks and one year. The most significant decrease occurred between the ages of 15 to 25 weeks. There was a no difference in total cholesterol concentrations due to sex. The serum triglyceride values ranged from 107 to 959 mg/dl with a mean of 394 mg/dl. There was an initial increase in triglyceride concentration from 367 to 565 mg/dl between two months and three months of age. However, the serum triglyceride concentration decreased to 349 mg/dl within one year of age. The serum triglyceride concentration was influenced by the sex of the rabbit. The mean male and female serum triglyceride concentrations were 510 mg/dl and 309 mg/dl respectively.