SERUM CHOLESTEROL VALUES OF THE NIH WHHL RABBIT

研究服务司兽医资源处 渡边高脂血症兔(WHHL)选育方法的建立 将菌落用作需要使用的调查人员的资源 这种动物模型。这个菌落的特征是血清 总胆固醇，脂蛋白各组份的胆固醇水平 和血清甘油三酯水平。血液被采集自 以下年龄的兔子：六周、三个月、七岁 几个月，一年。血清总胆固醇值范围 310~1251 mg/dl，平均828 mg/dl。低谷 密度脂蛋白(LDL)胆固醇值在1185之间 Mg/dl，平均630 mg/dl。因此，占总数的80% 胆固醇主要由低密度脂蛋白组成。有一个 血清总含量从885 mg/dl大幅降至576 mg/dl 胆固醇的年龄在八周到一岁之间。这个 最显著的下降发生在15岁至25岁之间 几周。在总胆固醇方面没有差别。 因性行为而导致的浓度。血清甘油三酯的值在 107~959 mg/dl，平均394 mg/dl。当时有一场 甘油三酯初始浓度从367增加到565 两个月到三个月龄之间的每分升毫克。然而， 血清甘油三酯浓度降至349 mg/dl 在一岁内。血清甘油三酯浓度为 受兔子性别的影响。卑鄙的男性和女性 血清甘油三酯浓度分别为510 mg/dl和309 mg/dl 分别进行了分析。

The Veterinary Resources Branch, Division of Research Services established a Watanabe Hyperlipidemic Rabbit (WHHL) breeding colony to be used as a resource for investigators requiring the use of this animal model. The colony is being characterized for serum total cholesterol, cholesterol levels of the lipoprotein fractions and serum triglyceride levels. Blood is being collected from rabbits at the following ages: six weeks, three months, seven months, and one year. Total serum cholesterol values ranged from 310 to 1251 mg/dl with a mean of 828 mg/dl. The low density lipoprotein (LDL) cholesterol values ranges from 1185 mg/dl with a mean of 630 mg/dl. Thus 80% of the total cholesterol was composed of LDL cholesterol. There was a substantial decrease from 885 to 576 mg/dl in serum total cholesterol between the ages of eight weeks and one year. The most significant decrease occurred between the ages of 15 to 25 weeks. There was a no difference in total cholesterol concentrations due to sex. The serum triglyceride values ranged from 107 to 959 mg/dl with a mean of 394 mg/dl. There was an initial increase in triglyceride concentration from 367 to 565 mg/dl between two months and three months of age. However, the serum triglyceride concentration decreased to 349 mg/dl within one year of age. The serum triglyceride concentration was influenced by the sex of the rabbit. The mean male and female serum triglyceride concentrations were 510 mg/dl and 309 mg/dl respectively.