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Risk factors of hepatocellular carcinoma in Haimen, China

海门市肝癌危险因素分析

基本信息

批准号：
06042014
负责人：
TOKUDOME Shinkan
金额：
$ 5.63万
依托单位：
Nagoya City University Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06042014/
关键词：
Haimen, China Hepatocellular carcinoma Host factors Environmental factors Hepatitis B virus Mycotoxins Microcystins Epidemiology HCV AFB_1

项目摘要

In order to prevent hepatocellular carcinoma (HCC) in Haimen, China, where the incidence of HCC is the highest in the world, an international multidisciplinary research is now underway sponsored by the Mombusho International Scientific Research Project, Special Cancer Research during 1995-1996.Microcystins, toxins produced by the algae in the creek, river and pond water and recently alleged to be promoters of hepatocarcinogenesis, were detected in the drinking water.Mycotoxins, such as aflatoxin B_1 and fumonisins, were detected in staple food, such as peanuts and corns.So far, 134 pairs of cases and controls were collected. Past history and family history of chronic hepatic diseases in cases were more frequent than controls. HCCs in Haimen were mainly associated with hepatitis B virus (HBV) but not hepatitis C virus. Both vertical infection and horizontal transmission of HBV may be responsible for the onset of HCCs. Neither smoking nor alcohol drinking were related to the onset of HCCs. Genetic polymorphisms of ALDH2 and CYP2E1 were not associated with HCCs. The activity of TNFalpha in cases was highter than controls.HCCs in Haimen were not necessarily related to liver cirrhosis or fibrosis. Aflatoxin B_1-associated specific mutations in p53 were observed.To prevent HCCs in Haimen, prevention of HBV infection seems most important and reduced intake of mycotoxin-polluted food are advised. In this study, a possible association between drinking water or microcystins and HCCs were not detected in this study.

为预防肝癌的发生，在中国海门市开展了一项国际性的多学科研究。1995- 1996年，Mombusho国际科学研究计划--癌症特别研究资助了海门市的一项研究。结果表明，在北京市的134对病例和对照中，均检出了黄曲霉毒素B_1和伏马菌素等真菌毒素，其中，在北京市的134对病例中检出了黄曲霉毒素B_1和伏马菌素。病例组有慢性肝病既往史和家族史者多于对照组。海门地区肝癌主要与B型肝炎病毒（HBV）有关，而与丙型肝炎病毒无关。HBV的垂直感染和水平传播可能是HCC发病的原因。吸烟和饮酒与肝癌的发病无关。ALDH 2和CYP 2 E1基因多态性与HCC无相关性。肝癌患者血清TNF α活性明显高于对照组，海门地区肝癌与肝硬化、肝纤维化无必然联系。预防海门地区肝癌的发生，首先要预防HBV感染，减少霉菌毒素污染的食物摄入。在这项研究中，饮用水或微囊藻毒素和肝细胞癌之间可能的关联在这项研究中没有检测到。