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Randomized controlled trial in patients polypectomized for benign adenomas/polyps of the colon

因结肠良性腺瘤/息肉而接受息肉切除术的患者的随机对照试验

基本信息

批准号：
08457137
负责人：
TOKUDOME Shinkan
金额：
$ 4.86万
依托单位：
Nagoya City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

项目摘要

Cancer, including colorectal cancer, is caused by the interaction between host and environmental factors together with an accumulation of gene alterations such as activation of oncogenes and inactivation of suppressor genes. Carcinogenesis progresses along with multi-factor, multi-hit and multi-stage mechanisum. Colorectal cancer proceeds largely through an adenoma-carcinoma sequence. Thus, the prevention of adenomas/polyps of the colon seems beneficial for reducing the onset of the cancer. We planned a ranomized controlled trial in the patients polypectomized for benign adenomas/polyps. The patients in the experimental group were advised to decrease their intake of fat as a whole and of foods containing n-6 polyunsaturated fatty acids(PUFA) such as vegetable oil and foods cooked with it, and to increase their intake of foods containing n-3 PUFA, including fish, perilla oil and fish oil. Those in the comparison group were advised to decrease intake of fat as a whole. Their compliance will be checked by measuring the concentration of fatty acid in the plasma, membrance of red blood cells and normal membrane of the colon. Biomarkers such as cell-cycle/proliferation markers, COX2-related proteins, PGE2 level, and apoptosis markers will be analyzed. In due course, the relapsing/onset rate of adenomas/polyps will be compared between experimental and comparison groups. The study is now ongoing, and its preliminary results in terms of compliance are reported here.

癌症，包括结直肠癌，是由宿主和环境因素之间的相互作用以及基因改变的积累引起的，例如癌基因的激活和抑制基因的失活。癌变过程是多因素、多打击、多阶段的机制。结直肠癌主要通过腺瘤-癌序列发展。因此，预防结肠腺瘤/息肉似乎有利于减少癌症的发生。我们计划对因良性腺瘤/息肉切除息肉的患者进行随机对照试验。建议实验组患者减少整体脂肪和含有n-6多不饱和脂肪酸（PUFA）的食物的摄入量，如植物油及其烹调的食物，并增加含有n-3 PUFA的食物的摄入量，包括鱼、紫苏油和鱼油。建议对照组的人总体上减少脂肪的摄入量。通过测量血浆、红细胞膜和正常结肠膜中的脂肪酸浓度来检查他们的依从性。将分析细胞周期/增殖标记物、COX2 相关蛋白、PGE2 水平和凋亡标记物等生物标记物。在适当的时候，将比较实验组和对照组之间的腺瘤/息肉的复发/发病率。该研究目前正在进行中，其在合规性方面的初步结果报告如下。