Randomized controlled trial in patients polypectomized for benign adenomas/polyps of the colon

包括结直肠癌在内的癌症是由宿主与环境因素相互作用以及致癌基因激活和抑制基因失活等基因改变的积累引起的。肿瘤的发生具有多因素、多打击、多阶段的机制。结直肠癌主要是通过腺瘤-癌序列进行的。因此，预防结肠腺瘤/息肉似乎有利于减少癌症的发生。我们计划在因良性腺瘤/息肉切除的患者中进行随机对照试验。建议实验组患者减少整体脂肪和含有n-6多不饱和脂肪酸（PUFA）的食物的摄入量，如植物油和用它烹饪的食物，增加含有n-3多不饱和脂肪酸的食物的摄入量，包括鱼、紫苏油和鱼油。对照组的人被建议整体上减少脂肪的摄入。他们的依从性将通过测量血浆、红血球膜和正常结肠膜中的脂肪酸浓度来检查。生物标志物，如细胞周期/增殖标志物，cox - 2相关蛋白，PGE2水平和凋亡标志物将进行分析。在适当的时候，我们将比较实验组和对照组之间腺瘤/息肉的复发率。该研究目前正在进行中，其依从性方面的初步结果在这里报告。

Cancer, including colorectal cancer, is caused by the interaction between host and environmental factors together with an accumulation of gene alterations such as activation of oncogenes and inactivation of suppressor genes. Carcinogenesis progresses along with multi-factor, multi-hit and multi-stage mechanisum. Colorectal cancer proceeds largely through an adenoma-carcinoma sequence. Thus, the prevention of adenomas/polyps of the colon seems beneficial for reducing the onset of the cancer. We planned a ranomized controlled trial in the patients polypectomized for benign adenomas/polyps. The patients in the experimental group were advised to decrease their intake of fat as a whole and of foods containing n-6 polyunsaturated fatty acids(PUFA) such as vegetable oil and foods cooked with it, and to increase their intake of foods containing n-3 PUFA, including fish, perilla oil and fish oil. Those in the comparison group were advised to decrease intake of fat as a whole. Their compliance will be checked by measuring the concentration of fatty acid in the plasma, membrance of red blood cells and normal membrane of the colon. Biomarkers such as cell-cycle/proliferation markers, COX2-related proteins, PGE2 level, and apoptosis markers will be analyzed. In due course, the relapsing/onset rate of adenomas/polyps will be compared between experimental and comparison groups. The study is now ongoing, and its preliminary results in terms of compliance are reported here.