Host and environmental factors of gastro-intestinal cancers in Southeast Asian countries.

东南亚国家胃肠癌的宿主和环境因素。

• 批准号: 17015040
• 负责人: TOKUDOME Shinkan
• 金额: $ 38.72万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17015040/
• 关键词: 東南アジア諸国; 胃がん; 大腸がん; 宿主要因; 環境要因; 国際エコロジカル研究; 症例対照研究; 東南アジア; ベトナム; タイ; インドネシア; エコロジカル研究

We conducted international ecological and case-control studies for gastric and colorectal cancers in Southeast Asian countries, including Vietnam, Thailand and Indonesia. International ecological studies in Indonesia have suggested that very low incidence of stomach cancer in six areas, in particular, may be due to low prevalence of Helicobacter pylori. The present case-control study for stomach cancer in Khon Kaen indicated that consumption of fruit and vegetables was a preventive factor. The study for colorectal cancer revealed that family history and consumption of red meat were risk factors. There were interactions between methylene tetra-hydro folate reductase genetic polymorphisms at codon A1298C and consumption of alcohol and red meat.

我们在东南亚国家（包括越南、泰国和印度尼西亚）进行了胃癌和结直肠癌的国际生态学和病例对照研究。在印度尼西亚进行的国际生态研究表明，特别是在六个地区，胃癌发病率非常低，这可能是由于幽门螺杆菌的流行率较低。目前在孔敬进行的胃癌病例对照研究表明，食用水果和蔬菜是一个预防因素。对结肠直肠癌的研究表明，家族史和红肉消费是危险因素。亚甲基四氢叶酸还原酶A1298C基因多态性与饮酒和红肉的摄入存在交互作用。

项目成果

Intake frequency of fish and serum levels of long-chain n-3 fatty acids: a cross-sectional study within the Japan Collaborative Cohort Study.

• DOI: 10.2188/jea.15.211
• 发表时间: 2005-11
• 期刊: Journal of epidemiology
• 影响因子: 4.7
• 作者: Wakai K;Ito Y;Kojima M;Tokudome S;Ozasa K;Inaba Y;Yagyu K;Tamakoshi A;JACC Study Group
• 通讯作者: JACC Study Group

Influence of the C161T but not Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma on colorectal cancer in an Indian population

• DOI: 10.1111/j.1349-7006.2005.00072.x
• 发表时间: 2005-08-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Jiang, J;Gajalakshmi, V;Tokudome, S
• 通讯作者: Tokudome, S

Relative validity of a short food frequency questionnaire for assessing nutrient intake versus three-day weighed diet records in middle-aged Japanese.

• DOI: 10.2188/jea.15.135
• 发表时间: 2005-07
• 期刊: Journal of epidemiology
• 影响因子: 4.7
• 作者: Tokudome Y;Goto C;Imaeda N;Hasegawa T;Kato R;Hirose K;Tajima K;Tokudome S
• 通讯作者: Tokudome S

Risk of endometrial cancer mortality by ever-use of sex hormones and other factors in Japan.

• 发表时间: 2006
• 期刊: Asian Pacific journal of cancer prevention : APJCP
• 作者: Mmh Khan;M. Mori;F. Sakauchi;Khandoker Aklimunnessa;T. Kubo;Y. Fujino;Sadao Suzuki;S. Tokudome;Akiko Tamakosh

Gastric and colo-rectal cancer mortality in Viet Nam in the Years 2005-2006

2005-2006 年越南胃癌和结直肠癌死亡率

• 发表时间: 2008
• 期刊: Asian Pac. J. Cancer Prev 9
• 作者: Ngoan;L.T. et.al.
• 通讯作者: L.T. et.al.