Host and environmental factors of gastro-intestinal cancers in Southeast Asian countries.

我们在东南亚国家（包括越南、泰国和印度尼西亚）进行了胃癌和结直肠癌的国际生态学和病例对照研究。在印度尼西亚进行的国际生态研究表明，特别是在六个地区，胃癌发病率非常低，这可能是由于幽门螺杆菌的流行率较低。目前在孔敬进行的胃癌病例对照研究表明，食用水果和蔬菜是一个预防因素。对结肠直肠癌的研究表明，家族史和红肉消费是危险因素。亚甲基四氢叶酸还原酶A1298C基因多态性与饮酒和红肉的摄入存在交互作用。

We conducted international ecological and case-control studies for gastric and colorectal cancers in Southeast Asian countries, including Vietnam, Thailand and Indonesia. International ecological studies in Indonesia have suggested that very low incidence of stomach cancer in six areas, in particular, may be due to low prevalence of Helicobacter pylori. The present case-control study for stomach cancer in Khon Kaen indicated that consumption of fruit and vegetables was a preventive factor. The study for colorectal cancer revealed that family history and consumption of red meat were risk factors. There were interactions between methylene tetra-hydro folate reductase genetic polymorphisms at codon A1298C and consumption of alcohol and red meat.