Hepatitis C virus and cirrhosis and hapatocellular carcinoma.

(1)生活方式和环境因素与丙型肝炎病毒（HCV）感染的关系正在研究中。(2)生活方式和环境因素与肝细胞癌（HCC）发病的关系正在研究中. (3)对3,237例无症状HCV携带者进行了随访研究。平均随访时间为2.7年。将观察到的死亡人数制成表格，并与使用日本一般人口死亡率计算的预期人数进行比较。计算观察到的/预期的死亡人数的比率。所有原因的O/E比降低，这是由选择偏倚或健康供体效应、观察期短以及基于一般人群而不是无HCV人群的预期数量解释的。肝细胞癌的O/E比值在男性和女性中均升高。GPT ≥ 36的受试者发生HCC的风险高于GPT ≤ 35的受试者。(4)目前，HCV基因型的准确分析方法已发展到流行病学和临床研究的阶段。

(1) Life style and environmental factors related to hepatitis C virus (HCV) infection are now investigated.(2) Life style and enviromental factors associated with the onset of hepatocellular carcinoma (HCC) are now studied.(3) Follow-up study of 3,237 asymptomatic HCV carriers was carried out. Average follow-up period was 2.7 years. The observed number of deaths was tabulated and compared with the expected numbers, which was calculated using the death rates of the general population of Japan. The ratio of observed/expected number of deaths was computed. The O/E ratio for all causes was decreased, which was explained by the selection bias or healthy donor effect, short observation period, and the expected numbers based on the general population instead of HCV-free population. The O/E ratio of hepatocellular carcinomawas elevated in males as well as in females. The risk of HCC among subjects with more than 36 of GPT was higher than that of those with 35 or less.(4) Accurate analytic methods of HCV genotype are now developed for epidemiologic and clinical studies.