Hepatitis C virus and cirrhosis and hapatocellular carcinoma.

丙型肝炎病毒与肝硬化和肝细胞癌。

• 批准号: 03670286
• 负责人: TOKUDOME Shinkan
• 金额: $ 1.22万
• 依托单位: Nagoya City University Medical School (1992-1993)佐賀医科大学 (1991)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670286/
• 关键词: Hepatitis C virus; Cirrhosis and hepatocellular carcinoma; Epidemiologic study; C型肝炎ウィルス; 感染ルート; 環境要因; 疫学; 追跡研究

(1) Life style and environmental factors related to hepatitis C virus (HCV) infection are now investigated.(2) Life style and enviromental factors associated with the onset of hepatocellular carcinoma (HCC) are now studied.(3) Follow-up study of 3,237 asymptomatic HCV carriers was carried out. Average follow-up period was 2.7 years. The observed number of deaths was tabulated and compared with the expected numbers, which was calculated using the death rates of the general population of Japan. The ratio of observed/expected number of deaths was computed. The O/E ratio for all causes was decreased, which was explained by the selection bias or healthy donor effect, short observation period, and the expected numbers based on the general population instead of HCV-free population. The O/E ratio of hepatocellular carcinomawas elevated in males as well as in females. The risk of HCC among subjects with more than 36 of GPT was higher than that of those with 35 or less.(4) Accurate analytic methods of HCV genotype are now developed for epidemiologic and clinical studies.

(1)生活方式和环境因素与丙型肝炎病毒（HCV）感染的关系正在研究中。(2)生活方式和环境因素与肝细胞癌（HCC）发病的关系正在研究中. (3)对3,237例无症状HCV携带者进行了随访研究。平均随访时间为2.7年。将观察到的死亡人数制成表格，并与使用日本一般人口死亡率计算的预期人数进行比较。计算观察到的/预期的死亡人数的比率。所有原因的O/E比降低，这是由选择偏倚或健康供体效应、观察期短以及基于一般人群而不是无HCV人群的预期数量解释的。肝细胞癌的O/E比值在男性和女性中均升高。GPT ≥ 36的受试者发生HCC的风险高于GPT ≤ 35的受试者。(4)目前，HCV基因型的准确分析方法已发展到流行病学和临床研究的阶段。

项目成果

Asakura,T.et al.: "Concomitant carriage of hepatitis B virus and human Tーlymphotropic virus type I among blood donors in Kitakyushu,Japan." J.Inf.23. 33-37 (1991)

Asakura, T. 等人：“日本北九州献血者中同时携带乙型肝炎病毒和人类嗜淋巴细胞病毒”，J.Inf.23 (1991)。

Tokudome, S.and Ohno, T.: "Follow-up study of asymptomatic HCV carriers." Jpn.J.Hygiene. 50. 527 (1995)

Tokudome, S. 和 Ohno, T.：“无症状 HCV 携带者的后续研究。”

Yamaguchi,K.,Tokudome,S.et al.: "Declining trends of HTLV-I prevalence among blood donors in Kumamoto,Japan." J.AIDS. 5. 533-534 (1992)

Yamaguchi,K.,Tokudome,S.et al.：“日本熊本县献血者中 HTLV-I 流行率呈下降趋势。”

Yonezawa,S.,Tokudome,S et al.: "Covalent coupling of a steroid to microwell plates for use in a competitive enzyme-linked immunosorbont assay." J.Immunol.Methods. 166. 55-61 (1993)

Yonezawa,S.,Tokudome,S 等人：“将类固醇与微孔板共价偶联，用于竞争性酶联免疫吸附测定。”