Hepatitis C virus and cirrhosis and hapatocellular carcinoma.

(1)研究了与丙型肝炎病毒感染相关的生活方式和环境因素。(2)研究了与肝细胞癌发病相关的生活方式和环境因素。(3)对3237名无症状的丙型肝炎病毒携带者进行了随访研究。平均随访时间为2.7年。观察到的死亡人数被制成表格，并与使用日本总人口死亡率计算的预期人数进行比较。计算观察死亡人数/预期死亡人数的比率。所有原因的O/E比下降，这是由于选择偏差或健康供体效应，观察期较短，以及以普通人群而不是无丙型肝炎人群为基础的预期数字。男性和女性肝细胞癌的O/E比值均高于男性。GPT>36者发生肝细胞癌的风险高于<35者。(4)建立了准确的丙型肝炎病毒基因分型方法，可用于流行病学和临床研究。

(1) Life style and environmental factors related to hepatitis C virus (HCV) infection are now investigated.(2) Life style and enviromental factors associated with the onset of hepatocellular carcinoma (HCC) are now studied.(3) Follow-up study of 3,237 asymptomatic HCV carriers was carried out. Average follow-up period was 2.7 years. The observed number of deaths was tabulated and compared with the expected numbers, which was calculated using the death rates of the general population of Japan. The ratio of observed/expected number of deaths was computed. The O/E ratio for all causes was decreased, which was explained by the selection bias or healthy donor effect, short observation period, and the expected numbers based on the general population instead of HCV-free population. The O/E ratio of hepatocellular carcinomawas elevated in males as well as in females. The risk of HCC among subjects with more than 36 of GPT was higher than that of those with 35 or less.(4) Accurate analytic methods of HCV genotype are now developed for epidemiologic and clinical studies.