Host and environmental factors of gastrointestinal tract cancers in the coastal area of Caspian Sea, Iran

伊朗里海沿海地区胃肠道癌症的宿主和环境因素

基本信息

  • 批准号:
    16406023
  • 负责人:
  • 金额:
    $ 9.15万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 财政年份:
    2004
  • 资助国家:
    日本
  • 起止时间:
    2004 至 2007
  • 项目状态:
    已结题

项目摘要

Objective: In order to prevent and control gastrointestinal cancers, including those of the esophagus, stomach and colorectum, in Babol, we conducted an ecological study and case-control studies.Subjects and Methods:Ecological study:We recruited 130 healthy people (50 men and 80 women) aged 30-80 yeaes in August 2004. Information on diet and lifestyle was obtained using a questionnaire. Urea breath test (UBT), Helicobacter pylori (H.pyloli) IgG antibodies, pepsinogen test and urinary excretions of sodium and potassium were determined for each participant. Human leukocyte antigen (HLA) and other genetic polymorphisms are analyzed.Case-controls studies:We thus collected 133 cases (96 men and 37 women) of stomach cancer, 45 cases (33 men and 12 women) and 22 cases (13 men and 9 women) of colorectal cancer. Information of diet and lifestyle was obtained using a questionnaire. UBT, H.pyloli IgG antibodies, pepsinogen test, anti-oxidant levels and fatty acid analysis are analyzed for each pa … More rticipant. Leukocyte antigen (HLA) and other genetic polymorphisms are being analyzed and interactions of host and environmental factors are examined.Results:Ecological study: Positive rates for UBT of 78% and 82% for men and women and H.pylori IgG antibodies of 69% and 74% for men and were higher than those in Japanese. Positive pepsinogen tests of 62% and 57% for men and women were also higher than in Japanese. Urinary excretions of salt and potassium in this population were the same as in Japanese. Higher stomach cancer mortality rate (SMR=138 vs. 100 for Japan) in women in Babol may be related to H.pylori infection, dietary habits and host genetic factors. In men, the lower level of gastric cancer mortality (SMR=83) than in Japan would suggests that smoking habits and host factors, together with the level of medical practice and prevalence of secondary prevention, rather than H.pylori infection itself, may be important.Case-control studies:A preliminary analysis is being done for stomach cancer, but the study subjects for the case-control studies are being recruited. Less
目的:为了预防和控制胃肠道肿瘤,包括食管癌、胃癌和结直肠癌,我们在Babol进行了一项生态学研究和病例对照研究。通过问卷调查获得有关饮食和生活方式的信息。对每位参与者进行尿素呼气试验(UBT)、幽门螺杆菌(H.pyloli)IgG抗体、胃蛋白酶原试验和尿钠和钾排泄测定。病例对照研究:收集胃癌133例(男96例,女37例),结直肠癌45例(男33例,女12例),结直肠癌22例(男13例,女9例)。通过问卷调查获得饮食和生活方式的信息。对每例患者进行UBT、幽门螺杆菌IgG抗体、胃蛋白酶原试验、抗氧化剂水平和脂肪酸分析。 ...更多信息 rticipant。白细胞抗原(HLA)和其他遗传多态性正在分析和宿主和环境factors.Results的相互作用:生态学研究:阳性率为78%和82%的UBT的男性和女性和幽门螺杆菌IgG抗体的69%和74%的男性,高于日本人。男性和女性的胃蛋白酶原检测阳性率分别为62%和57%,也高于日本人。该人群的尿盐和钾排泄量与日本人相同。Babol地区女性胃癌死亡率较高(SMR=138,日本为100),可能与幽门螺杆菌感染、饮食习惯和宿主遗传因素有关。男性胃癌死亡率(SMR=83)低于日本,这表明吸烟习惯和宿主因素,以及医疗实践水平和二级预防的流行程度,而不是幽门螺杆菌感染本身,可能是重要的。病例对照研究:正在对胃癌进行初步分析,但病例对照研究的研究对象正在招募中。少

项目成果

期刊论文数量(76)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Is the proportion of infection-related cancers much greater than generally appreciated?
与感染相关的癌症的比例是否比普遍认为的要高得多?
  • DOI:
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Nishio;K;Atsuta Y;Mutoh H;Mikami H;Hirose K;Kuriki K;Tokudome S;Kojima M;Tokudome S
  • 通讯作者:
    Tokudome S
「研究成果報告書概要(和文)」より
摘自《研究结果报告摘要(日文)》
  • DOI:
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Kawauchi;et. al.;Nishimura et al.;Dezawa et al.;Yoshizawa et al.;星野 幹雄;星野 幹雄
  • 通讯作者:
    星野 幹雄
Consumption of soy foods and the risk of breast cancer: findings from the Japan Collaborative Cohort (JACC) Study
  • DOI:
    10.1007/s10552-007-9023-7
  • 发表时间:
    2007-10-01
  • 期刊:
  • 影响因子:
    2.3
  • 作者:
    Nishio, Kazuko;Niwa, Yoshimitsu;Tamakoshi, Akiko
  • 通讯作者:
    Tamakoshi, Akiko
標準公衆衛生・社会医学
标准公共卫生/社会医学
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Tokudome;S;徳留信寛;徳留信寛;徳留信寛
  • 通讯作者:
    徳留信寛
Black tea and cardiovascular disease.
红茶与心血管疾病。
  • DOI:
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Tokudome;S. et al.
  • 通讯作者:
    S. et al.
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TOKUDOME Shinkan其他文献

TOKUDOME Shinkan的其他文献

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{{ truncateString('TOKUDOME Shinkan', 18)}}的其他基金

Cohort study of morbidity and mortality from lifestyle-related diseases among Japanese dietitians
日本营养师生活方式相关疾病发病率和死亡率的队列研究
  • 批准号:
    19390177
  • 财政年份:
    2007
  • 资助金额:
    $ 9.15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Host and environmental factors of gastro-intestinal cancers in Southeast Asian countries.
东南亚国家胃肠癌的宿主和环境因素。
  • 批准号:
    17015040
  • 财政年份:
    2005
  • 资助金额:
    $ 9.15万
  • 项目类别:
    Grant-in-Aid for Scientific Research on Priority Areas
Appropriate exercise levels for health promotion based on biomarkers of habitual aerobic exercisers
基于习惯性有氧运动者的生物标志物促进健康的适当运动水平
  • 批准号:
    15390208
  • 财政年份:
    2003
  • 资助金额:
    $ 9.15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Randomized controlled trial in patients polypectomized for benign adenomas/polyps of the colon
因结肠良性腺瘤/息肉而接受息肉切除术的患者的随机对照试验
  • 批准号:
    08457137
  • 财政年份:
    1996
  • 资助金额:
    $ 9.15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Risk factors of hepatocellular carcinoma in Haimen, China
海门市肝癌危险因素分析
  • 批准号:
    08042010
  • 财政年份:
    1996
  • 资助金额:
    $ 9.15万
  • 项目类别:
    Grant-in-Aid for international Scientific Research
Risk factors of hepatocellular carcinoma in Haimen, China
海门市肝癌危险因素分析
  • 批准号:
    06042014
  • 财政年份:
    1994
  • 资助金额:
    $ 9.15万
  • 项目类别:
    Grant-in-Aid for international Scientific Research
Dietary habits and lifestyle and health among Japanese dietitians.
日本营养师的饮食习惯、生活方式和健康。
  • 批准号:
    06454242
  • 财政年份:
    1994
  • 资助金额:
    $ 9.15万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
Hepatitis C virus and cirrhosis and hapatocellular carcinoma.
丙型肝炎病毒与肝硬化和肝细胞癌。
  • 批准号:
    03670286
  • 财政年份:
    1991
  • 资助金额:
    $ 9.15万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
Follow-up study of non-A, non-B post-transfusion hepatitis
非甲非乙型输血后肝炎的随访研究
  • 批准号:
    63570257
  • 财政年份:
    1988
  • 资助金额:
    $ 9.15万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)

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A Human Sensory Neuron Model of VZV Infection
VZV 感染的人类感觉神经元模型
  • 批准号:
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水痘带状疱疹轴突运输和持续性的新体外神经元模型
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    8487903
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    2013
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    $ 9.15万
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A new in vitro neuron model of axonal transport and persistence of varicella zost
水痘带状疱疹轴突运输和持续性的新体外神经元模型
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脉冲神经元模型的监督学习规则
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