Host and environmental factors of gastrointestinal tract cancers in the coastal area of Caspian Sea, Iran

目的：为了预防和控制巴波尔的食道癌、胃癌和结直肠癌等胃肠道癌症，我们进行了生态学研究和病例对照研究。对象和方法：生态学研究：我们于2004年8月招募了130名健康人（50名男性和80名女性），年龄30-80岁。通过问卷调查获得有关饮食和生活方式的信息。对每位参与者进行尿素呼气试验（UBT）、幽门螺杆菌（H.pyloli）IgG抗体、胃蛋白酶原试验和尿钠和钾排泄测定。病例对照研究：收集胃癌133例（男96例，女37例），结直肠癌45例（男33例，女12例），结直肠癌22例（男13例，女9例）。通过问卷调查获得饮食和生活方式的信息。对每例患者进行UBT、幽门螺杆菌IgG抗体、胃蛋白酶原试验、抗氧化剂水平和脂肪酸分析。 关于我们 rticipant。白细胞抗原（HLA）和其他遗传多态性正在分析和宿主和环境factors.Results的相互作用：生态学研究：阳性率为78%和82%的UBT的男性和女性和幽门螺杆菌IgG抗体的69%和74%的男性，高于日本人。男性和女性的胃蛋白酶原检测阳性率分别为62%和57%，也高于日本人。该人群的尿盐和钾排泄量与日本人相同。Babol地区女性胃癌死亡率较高（SMR=138，日本为100），可能与幽门螺杆菌感染、饮食习惯和宿主遗传因素有关。男性胃癌死亡率（SMR=83）低于日本，这表明吸烟习惯和宿主因素，以及医疗实践水平和二级预防的流行程度，而不是幽门螺杆菌感染本身，可能是重要的。病例对照研究：正在对胃癌进行初步分析，但病例对照研究的研究对象正在招募中。少

Objective: In order to prevent and control gastrointestinal cancers, including those of the esophagus, stomach and colorectum, in Babol, we conducted an ecological study and case-control studies.Subjects and Methods:Ecological study:We recruited 130 healthy people (50 men and 80 women) aged 30-80 yeaes in August 2004. Information on diet and lifestyle was obtained using a questionnaire. Urea breath test (UBT), Helicobacter pylori (H.pyloli) IgG antibodies, pepsinogen test and urinary excretions of sodium and potassium were determined for each participant. Human leukocyte antigen (HLA) and other genetic polymorphisms are analyzed.Case-controls studies:We thus collected 133 cases (96 men and 37 women) of stomach cancer, 45 cases (33 men and 12 women) and 22 cases (13 men and 9 women) of colorectal cancer. Information of diet and lifestyle was obtained using a questionnaire. UBT, H.pyloli IgG antibodies, pepsinogen test, anti-oxidant levels and fatty acid analysis are analyzed for each pa … More rticipant. Leukocyte antigen (HLA) and other genetic polymorphisms are being analyzed and interactions of host and environmental factors are examined.Results:Ecological study: Positive rates for UBT of 78% and 82% for men and women and H.pylori IgG antibodies of 69% and 74% for men and were higher than those in Japanese. Positive pepsinogen tests of 62% and 57% for men and women were also higher than in Japanese. Urinary excretions of salt and potassium in this population were the same as in Japanese. Higher stomach cancer mortality rate (SMR=138 vs. 100 for Japan) in women in Babol may be related to H.pylori infection, dietary habits and host genetic factors. In men, the lower level of gastric cancer mortality (SMR=83) than in Japan would suggests that smoking habits and host factors, together with the level of medical practice and prevalence of secondary prevention, rather than H.pylori infection itself, may be important.Case-control studies:A preliminary analysis is being done for stomach cancer, but the study subjects for the case-control studies are being recruited. Less