Follow-up study of non-A, non-B post-transfusion hepatitis

非甲非乙型输血后肝炎的随访研究

• 批准号: 63570257
• 负责人: TOKUDOME Shinkan
• 金额: $ 1.09万
• 依托单位: Saga Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63570257/
• 关键词: Blood transfusion; Non-A, non-B hepatitis; Cirrhosis and hepatocellular carcinoma; Follow-up; 輸血後肝炎; B型肝炎ウィルス; C型肝炎ウィルス; 慢性肝炎; 肝硬変; 肝がん; 長期追跡; コホ-ト研究; 非A非 B肝炎; 慢性肝疾患

Follow-up study of non-A, non-B post-tansfusion hepatitis among 4, 289 patients who had undergone partial gastrectomy for benign gastroduodenal diseases at university hospitals was carried out. Their medical records were reviewed and information on individual identification, underlying disease, type of operation. date of operation, volume of transfusion, and smoking and drinking habits was obtained. Vital status was located by using Koseki system and death certificates were referred to the Legal Affairs Bureau when patients were deceased. Observed number of deaths was compared with the expected number, which was calculated by applying person-years at risk with calendar-, cause-, sex- and age-specific mortality rates in Japan. Mortality from hepatocellular carcinoma among patients who received transfusion was elevated and the risk was correlated with the volume of transfusion. Latency period between transfusion and death from hepatocellular carcinoma was 21 years on average. Follow-up of hepatitis C virus carriers is now under way to specifically examine the association between hepatitis C virus and cirrhosis and hepatocellular carcinoma.

对4289例在大学医院接受胃十二指肠良性疾病胃大部切除术的患者进行了输血后非甲、非乙型肝炎的随访研究。对他们的医疗记录进行了审查，并提供了有关个人身份、潜在疾病和手术类型的信息。记录手术日期、输血量、吸烟和饮酒习惯。使用Koseki系统确定生命状态，并在患者死亡时将死亡证明提交给法律事务局。将观察到的死亡人数与预期死亡人数进行比较，预期死亡人数是根据日本的历年、死因、性别和年龄特定死亡率计算得出的。在接受输血的患者中，肝细胞癌的死亡率较高，且风险与输血量相关。从输血到死于肝细胞癌的潜伏期平均为21年。目前正在对丙型肝炎病毒携带者进行随访，以具体检查丙型肝炎病毒与肝硬变和肝细胞癌之间的联系。

项目成果

Tokudome,S.et al.: "Hepatocellular carcinoma among female japanese hepatitis B virus acrriers." Hepato-Gastroenterol.34. 246-248 (1987)

Tokudome,S.et al.：“女性日本乙型肝炎病毒携带者中的肝细胞癌。”

Tokudome, S. et al.: "Hepatocellular carcinoma among HBsAg positive blood donors in Fukuoka, Japan." Eur. J. Cancer Clin. Oncol.24. 235-239 (1988)

Tokudome, S. 等人：“日本福冈 HBsAg 阳性献血者中的肝细胞癌。”

Tokudome, S.: "Risk of gastric remnant cancer in Japan." Jpn. J. Cancer Res.82. 871-872 (1991)

Tokudome, S.：“日本残胃癌的风险。”

福田 篤志、ほか: "輸血歴と肝硬変・肝癌発生に関する臨床疫学的研究" 消化器癌の発生と進展. 2. 153-156 (1990)

Atsushi Fukuda 等：“输血史与肝硬化和肝癌发生的临床流行病学研究”胃肠癌的发生和进展（1990 年）。

Maeda,Y.et al.: "Time trends of HBsAg prevalence among blood donors in fukuoka,Japan." Eur.J.Epidemiol.

Maeda,Y.et al.：“日本福冈献血者中 HBsAg 患病率的时间趋势。”