Development of spiral-vortex-type blood pump (Optimal design and its application to cardiomyoplasty)

螺旋涡流式血泵的研制（优化设计及其在心肌成形术中的应用）

• 批准号: 06044025
• 负责人: NAKAMURA Takao
• 金额: $ 3.65万
• 依托单位: Hokkaido University (1995-1996)Yamagata University (1994)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06044025/
• 关键词: spiral-vortex; blood pump; pump surface property; cardiomyoplasty; pump flow; Artificial Heart Pump; Cardiomyoplasty; Laser Doppler Anemometry; Pump Flow; Spiral-Vortex

A spiral-vortex-type blood pump is one of the promising pumps having the best fluid dynamic characteristics to control the thrombus formation inside the pump. To develop a total system of the pump and for an application of it to the cardiomyoplasty, following studies have been conducted.(1) A new system for the measurement of pump flow was designed, based on a principle that the electrical capacitance of electrodes attached to the pump surface changes depending on the blood volume inside the pump. A preliminary test in vitro has shown excellent results.(2) An economical method for the fabrication of the blood pump has been designed, using vacuum forming and injection molding. Using the technique, several pumps with different physical shapes were fabricated, and basic performance of them has been tested and compared with each others for the empirical optimization of pump shape.(3) A new economical ball valve with plastic housing has been designed for the blood pump application. A preliminary test in vitro has proven an excellent fluid dynamical performance of the valve.(4) Effect of rough surface of polymer materials on the thrombogenisity have been analyzed quantitatively. The surface of the polymer was fabricated quantitatively textured (physical length and interval) with laser beam, and the polymer has been implanted in sheep. The experiments are still on the way.(5) Basic mechanical characteristics (energetics) of the pump diaphragm have been analyzed for the future application of cardiomyoplasty.(6) Flow pattern inside the pump has been measured by laser Doppler anemometry. The analyzing software has been developed, and the results have been displayd in animation.(7) Acute animal experiments have been conducted for test the feasibility of blood pump system. The pumps have shown excellent spiral-vortex inside the pump.

螺旋涡流型血泵是控制泵内血栓形成的最有前途的泵之一，具有良好的流体动力学特性。为了开发一套完整的泵系统，并将其应用于心肌成形术，开展了以下研究工作：(1)设计了一种新型的泵流量测量系统，其原理是连接在泵表面的电极的电容随泵内血流量的变化而变化。初步的体外试验结果良好。(2)采用真空成型和注射成型相结合的方法，设计了一种经济实用的血泵制造方法。利用该技术制造了几种不同物理形状的泵，并对它们的基本性能进行了测试和比较，为泵的形状优化提供了经验依据。(3)针对血泵的应用，设计了一种新型的经济型塑料外壳球阀。初步的体外试验证明了该阀门具有良好的流体动力学性能。(4)定量分析了聚合物材料表面粗糙对其凝血性能的影响。用激光对聚合物表面进行了定量织构(物理长度和间距)，并将其植入绵羊体内。实验仍在进行中。(5)对泵隔膜的基本力学特性(能量学)进行了分析，为今后的心肌成形术应用奠定了基础。(6)利用激光多普勒测速仪测量了泵内的流态。开发了分析软件，并以动画形式显示了分析结果。(7)为验证血泵系统的可行性，进行了急性动物实验。泵内部表现出良好的螺旋涡流。

项目成果

Allen H.Nugent,et al.: "LDA measurements of flow in the 'spiral vortex' VAD" Proc.2nd World Cong.of Biomechanics. 283- (1994)

Allen H.Nugent 等人：“‘螺旋涡’VAD 中流量的 LDA 测量”Proc.2nd World Cong.of Biomechanics。

Naoki Fujisawa, et al.: "Energy dissipation of diaphragms for a pneumatically driven artificial heart" Heart Replacement-Artificial Heart 5. 259-264 (1996)

Naoki Fujisawa 等人：“气动驱动人工心脏隔膜的能量耗散”Heart Replacement-Artificial Heart 5. 259-264 (1996)

Naoki Fujisawa,et al.: "Development and evaluation of a textured blood contacting surface" Proc.Waseda Internat.Cong.of Modeling and Simulation Technology for Artif Organs. 129-130 (1996)

Naoki Fujisawa 等人：“有纹理的血液接触表面的开发和评估”Proc.Waseda Internat.Cong.of Artif Organs 建模和模拟技术。

Allen H.Nugent,et al.: "LDA measurements of flow in the 'spiral vortex' VAD" Proc.2nd World Cong.of Biomechanics. 283 (1994)

Allen H.Nugent 等人：“‘螺旋涡’VAD 中流量的 LDA 测量”Proc.2nd World Cong.of Biomechanics。

Naoki Fujisawa,et al.: "Energy dissipation of diaphragms for a pneumatically driven artificial heart" Heart Replacement-Artificial Heart 5. 259-264 (1996)

Naoki Fujisawa 等人：“气动驱动人工心脏隔膜的能量耗散”心脏置换-人工心脏 5. 259-264 (1996)