权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Analysing system for homeostatic control during exercise.

运动期间稳态控制的分析系统。

基本信息

批准号：
07557189
负责人：
KANOSUE Kazuyuki
金额：
$ 2.3万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1997
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07557189/
关键词：
Exercise Homeostasis wheel rat unanesthetized animal

项目摘要

During exercise regulatory systems for maintaining homeostasis, such as cardiovascular and respiratory ones, work in harmony to fulfilll the efficient musculare activities. There are two routs for accomplishing this well-organized integrations of homeostatic regulation. One is negative feedback system which is brought into action with the neuronal or humoral signls from the muscles or joints concerning the movement of the limb or metabolism. The other is the feed foreward system which is triggered by the signals from the higher motor center to the autonomic nervous systems (cemtral command). The brain mechanisms especially for this feed foreward system is totally unknown. One of the reason is there is no proper animal models to study this question. The purpose of this study is to develop a system for measuring autonomic functions from the spontaneously exercising rats. The experiment were made in Wister male rats. We used rotating wheels in which a rat ran. The rat was implanted with two telemeters, one for measuring blood pressure and heart rate and the other for measuring EMG.The rotation of the wheel (movement of the rat) and the output from the telemeters were fed into the computer. A program for analyzing temporal relations between rat's movement and the change in blood pressure or heart rate was made. Rats ealily mastered running in the wheel, and it was ovserved a simultaneous blood pressure change with running movement. The present system would become a very powerful tool for analyzing the neuronal mechanisms for controlling homeostasis during exercise.

在运动过程中，维持体内平衡的调节系统，如心血管系统和呼吸系统，协调工作，以实现有效的肌肉活动。有两种途径可以实现这种有组织的自我平衡调节的整合。一种是负反馈系统，它通过肌肉或关节上有关肢体运动或新陈代谢的神经元或体液信号发挥作用。另一种是前馈系统，由高级运动中枢向自主神经系统发出的信号触发(中枢指令)。大脑机制，特别是这种前馈系统的机制是完全未知的。原因之一是没有合适的动物模型来研究这个问题。本研究的目的是开发一套测量自发运动大鼠自主神经功能的系统。实验是在Wistar雄性大鼠身上进行的。我们使用旋转的轮子，一只老鼠在轮子上跑。在大鼠体内植入两个遥测仪，一个用于测量血压和心率，另一个用于测量肌电。轮子的旋转(大鼠的运动)和遥测仪的输出被输入计算机。编制了大鼠运动与血压、心率变化之间的时间关系分析程序。大鼠在方向盘中积极地掌握了跑步，而且随着跑步运动的进行，它的血压变化是同步的。目前的系统将成为一个非常强大的工具，以分析在运动中控制体内平衡的神经元机制。