Analysing system for homeostatic control during exercise.

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During exercise regulatory systems for maintaining homeostasis, such as cardiovascular and respiratory ones, work in harmony to fulfilll the efficient musculare activities. There are two routs for accomplishing this well-organized integrations of homeostatic regulation. One is negative feedback system which is brought into action with the neuronal or humoral signls from the muscles or joints concerning the movement of the limb or metabolism. The other is the feed foreward system which is triggered by the signals from the higher motor center to the autonomic nervous systems (cemtral command). The brain mechanisms especially for this feed foreward system is totally unknown. One of the reason is there is no proper animal models to study this question. The purpose of this study is to develop a system for measuring autonomic functions from the spontaneously exercising rats. The experiment were made in Wister male rats. We used rotating wheels in which a rat ran. The rat was implanted with two telemeters, one for measuring blood pressure and heart rate and the other for measuring EMG.The rotation of the wheel (movement of the rat) and the output from the telemeters were fed into the computer. A program for analyzing temporal relations between rat's movement and the change in blood pressure or heart rate was made. Rats ealily mastered running in the wheel, and it was ovserved a simultaneous blood pressure change with running movement. The present system would become a very powerful tool for analyzing the neuronal mechanisms for controlling homeostasis during exercise.