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Development and evaluation of durable hybrid-type artificial ligament composed of high molecular synthetic fibers and human collagen fiber bundles

高分子合成纤维与人胶原纤维束组成的耐用混合型人工韧带的开发与评价

基本信息

批准号：
07558118
负责人：
YASUDA Kazunori
金额：
$ 8.45万
依托单位：
HOKKAIDO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1997
项目状态：
已结题

项目摘要

l.Tensile tests after implantation demonstrated that the strength of the polyester fiber is the greatest in synthetic fibers which have favorable histocompatibility and clinical utility.2.The tensile strength of the semitendinosus tendon is the greatest (124.3 MPa) in the collagen fiber bundles harvested from human body.3.The alpha-type connection method between flatly knit polyester fibers and looped flexor tendons is the strongest in serial connection methods between synthetic fibers and human collagen fiber bundles.4.The tensile strength of the femur-graft-tibia complex that has undergone ACL reconstruction using the hybrid-type synthetic ligament, where flatly knit polyester fibers are connected in series with human collagen fiber bundles using the alpha -type connection method, is approximately 900N.It is the greatest in the complexes reconstructed with currently available procedures, and is resistant to submaximal cyclic loading.5.The collagen bundle portion in the hybrid-type sy … More nthetic ligament is fixed by thick connective tissues in bone tunnels at 6 weeks postoperatively. The fixation strength is not affected by disagreement of the diameter between a graft and a bone tunnel.6.The tensile strength of the collagen fiber bundle portion of the hybrid-type synthetic ligament changes into 59,50,5l, and 56% at 3,6,9,12, and 24 weeks, respectively, after implantation. The deterioration rate is less than that of the patellar tendon autograft at each period.7.The tensile strength of the grafted collagen fiber bundle portion is deteriorated by both stress deprivation and stress enhancement. The deterioration rate, however, is less than that of the patellar tendon autograft.8.Based on the above-described basic data, a clinically available hybrid-type synthetic ligament composed of synthetic polyester fibers and human collagen fiber bundles has been developed, and evaluated clinically in 110 cases of ACL reconstruction. The result demonstrated that normal stability is restored in 91% of the knees. This result is superior to that reported in previous literature. Less

1.植入后的拉伸试验表明，聚酯纤维的强度是合成纤维中最大的，具有良好的组织相容性和临床实用性。2.从人体采集的胶原纤维束中，半腱肌腱的拉伸强度最大(124.3 Mpa)。3.在合成纤维与人胶原纤维束的串联连接方法中，扁平编织的聚酯纤维与环状屈肌腱之间的Alpha型连接方式最强。4.利用杂交型合成韧带重建前交叉韧带后的股骨-移植物-胫骨复合体的抗拉强度，其中，平织涤纶纤维与人胶原纤维束使用阿尔法型连接方法串联，约为900N。这是用当前可用的程序重建的复合体中最大的，并且抵抗次最大循环载荷。5.杂交型SY…中的胶原束部分术后6周更多的人工韧带被粗大的结缔组织固定在骨隧道内。植入后3周、6周、9周、12周和24周，复合型合成韧带的胶原纤维束部分的拉伸强度分别为59、50、51和56%。7.应力剥夺和应力增强均使移植的胶原纤维束部分的抗拉强度降低。8.在上述基础数据的基础上，研制了一种可用于临床的合成纤维和人胶原纤维束杂交型合成韧带，并在110例前交叉韧带重建中进行了临床评价。结果表明，91%的膝关节恢复了正常的稳定性。这一结果优于以往文献报道的结果。较少