Development and evaluation of durable hybrid-type artificial ligament composed of high molecular synthetic fibers and human collagen fiber bundles

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l.Tensile tests after implantation demonstrated that the strength of the polyester fiber is the greatest in synthetic fibers which have favorable histocompatibility and clinical utility.2.The tensile strength of the semitendinosus tendon is the greatest (124.3 MPa) in the collagen fiber bundles harvested from human body.3.The alpha-type connection method between flatly knit polyester fibers and looped flexor tendons is the strongest in serial connection methods between synthetic fibers and human collagen fiber bundles.4.The tensile strength of the femur-graft-tibia complex that has undergone ACL reconstruction using the hybrid-type synthetic ligament, where flatly knit polyester fibers are connected in series with human collagen fiber bundles using the alpha -type connection method, is approximately 900N.It is the greatest in the complexes reconstructed with currently available procedures, and is resistant to submaximal cyclic loading.5.The collagen bundle portion in the hybrid-type sy … More nthetic ligament is fixed by thick connective tissues in bone tunnels at 6 weeks postoperatively. The fixation strength is not affected by disagreement of the diameter between a graft and a bone tunnel.6.The tensile strength of the collagen fiber bundle portion of the hybrid-type synthetic ligament changes into 59,50,5l, and 56% at 3,6,9,12, and 24 weeks, respectively, after implantation. The deterioration rate is less than that of the patellar tendon autograft at each period.7.The tensile strength of the grafted collagen fiber bundle portion is deteriorated by both stress deprivation and stress enhancement. The deterioration rate, however, is less than that of the patellar tendon autograft.8.Based on the above-described basic data, a clinically available hybrid-type synthetic ligament composed of synthetic polyester fibers and human collagen fiber bundles has been developed, and evaluated clinically in 110 cases of ACL reconstruction. The result demonstrated that normal stability is restored in 91% of the knees. This result is superior to that reported in previous literature. Less