Study of retrovirus-specific T cell responses in Sjogren syndrome.

干燥综合征逆转录病毒特异性 T 细胞反应的研究。

• 批准号: 07670538
• 负责人: TAKEDA Akira
• 金额: $ 1.47万
• 依托单位: Jichi Med School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670538/
• 关键词: Sjogren Syndrome; Retrovirus; T cells from salivary glands; 逆転写酵素

The possible role of retroviruses in the pathogenesis of Sjogren's syndrome (SS) has been suggested. However, the evidence has been circumstantial and it is not known at all whether cellular immune responses to retroviruses are linked to the mechanism of the disease. Although the oligoclonal expansion of T lymphocytes in salivary glands of SS has been indicated by analyzes of T cell receptor usage, the corresponding ligands are unknown. An important question is of whether this disorder involves virus specific immune attaks on the salivary tissue which may be a site for retroviruses latency. We introduced our unique functional study of the salivary gland-infiltrating T lymphocytes in patients with SS for detecting retrovirus specific memory T lymphocyts. Our results of the study suggested no potential association of the state of retrovirus-specific immune responses in the lesion with the disease. We also could not find any evidence for retrovirus infection in the salivary tissues from patients with SS.

逆转录病毒在干燥综合征（SS）发病机制中的可能作用已被提出。然而，证据一直是间接的，并且根本不知道对逆转录病毒的细胞免疫应答是否与疾病的机制有关。虽然SS唾液腺中T淋巴细胞的寡克隆扩增已通过T细胞受体使用的分析表明，但相应的配体是未知的。一个重要的问题是，这种疾病是否涉及病毒特异性免疫攻击的唾液组织，这可能是一个网站的逆转录病毒潜伏期。我们介绍了我们独特的功能研究唾液腺浸润T淋巴细胞在SS患者检测逆转录病毒特异性记忆T淋巴细胞。我们的研究结果表明，病变中逆转录病毒特异性免疫反应的状态与疾病没有潜在的联系。我们也没有发现任何证据表明逆转录病毒感染的唾液组织中的SS患者。

项目成果

Akira Takeda, et al.: "Functional analysis of T cells from salivary glands in Sjogren's syndrome." Clin.Rheum.14. 46 (1995)

Akira Takeda 等人：“干燥综合征唾液腺 T 细胞的功能分析。”

Eiji Sada, et al.: "Detection of human herpesvirus 6 and 7 in salivary glands by PCR." J.Clm.Microbiol.34. 2320-2321 (1996)

Eiji Sada 等人：“通过 PCR 检测唾液腺中的人类疱疹病毒 6 型和 7 型”。

Akira Takeda, et al.: "Immunological study of tissue-infiltrating lymphocgtes in Sjigren's Jyad." Clin,Rheum.14. 46 (1995)

Akira Takeda 等人：“Sjigrens Jyad 中组织浸润淋巴细胞的免疫学研究。”

Eiji Sada, et al.: "Detection of human herpesvirns 6 and 7 in the submandibular gland, parotid gland, and lip salivary gland by PCR." J.Clin.Microbiol.34. 2320-2321 (1996)

Eiji Sada 等人：“通过 PCR 检测下颌下腺、腮腺和唇唾液腺中的人类疱疹病毒 6 和 7。”

Akira Takeda, et al.: "Immunological study of tissue-infiltrating lymphocytes in Sjogren's syndrome." Nippon Rinsho. 53. 2484-2489 (1995)

Akira Takeda 等人：“干燥综合征组织浸润淋巴细胞的免疫学研究。”