Influence of the chronic pain on skin wound healing

临床上，感觉受损区域的伤口愈合通常是棘手的。分析皮肤创伤愈合过程中神经因素的状态。在大鼠背部建立感觉障碍区，并与健侧进行比较。正常皮肤真皮和神经纤维中检测到P物质，而感觉受损区神经中7天后未检测到P物质。外源性P物质促进感觉受损区创面愈合

Clinically, wound healing in sensory impaired areas is often intractable. The state of neural factor about skin wound healing was analyzed. The sensory impaired area was created the back of the rat, and it compared with the healthy part. Although the substance P in dermis and nerve fiber was identified on the healthy skin, it was not detected in the nerve of sensory impaired areas after the 7thday. Exogenous Substance P promoted the wound healing of sensory impaired areas