Physioengineering approach to the autonomic nervous control of the heart rate fluctuations in developing embryos.

发育胚胎中自主神经控制心率波动的生理工程方法。

基本信息

批准号：
08650471
负责人：
TAZAWA Hiroshi
金额：
$ 1.41万
依托单位：
Muroran Institute of Tehnology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1997
项目状态：
已结题

项目摘要

1.Daily changes (developmental patterns) of embryonic heart rate (HR) of the king quail (mean egg mass=about 6g) were determined during the whole incubation period. Allometric equation of HR in 9 species of the precocial birds including the king quail and ostrich was redulted in HR=440・M^<-0.128> (M=egg mass in g).2.Developmental patterns of embryonic HR in chickens were determined by impedancecardiogrpahy during the first half of incubation without impeding gas exchange through the eggshell. Additionally, the responses of embryonic HR to 10% O_2 and 100% O_2 exposoures were investigated.3.Embryonic HR of chickens was measured continously by acoustocardiography throughout the last half of incubation. In addition to the HR irregularities which began to appear on days 14-16, the HR variability (cyclic oscillation) with period of 0.5-1 hour was found to appear on these days and the magnitude of the oscillation became augmented with embryonic development.4.It was found that appearance and time course of respiratory movements due to lung ventilation of embryos prior to and during internal pipping could be recorded by acoustocardiography. This is the new finding which may contribute to an investigation of ontogenic mechanism of pulmonary gas exchange in avian embryos.5.Using the electrocardiography, we could record the HR fluctuations of chick embryos during internal and external pipping period. It was found that the HR variability and irregularities and their time course were particularly unique in external pipping embryos.6.Autonomic nervous controls of the HR fluctuations during the prenatal development of chick embyos were investigated by dosing intravenously the various autonomic drugs. It was found that the transient deceleration of HR was produced by parasympathetic nervous functions. But, the relation between sympathetic nervous functions and various patterns of HR accleration was not clear and need further investigation.

1。在整个孵化期间确定了国王鹌鹑的胚胎心率（HR）的每日变化（发育模式）。在9种早产鸟类中，HR在内的HR的异形方程在HR = 440 ・M^<-0.128>中降低了（M = G）。2。鸡肉中胚胎HR的开发模式在Impedancecardiogrpahy中通过ImpedCardiogrPahy在不融合的情况下通过InveDeDecshell in ImpeDeDeDeDeDeDeedeDeDecshell确定。此外，研究了胚胎HR对10％O_2和100％O_2暴露的反应。3。在整个孵育的最后一半中，通过含水心动图连续测量了鸡的Embryonic HR。除了在第14-16天开始出现的人力资源不规则之外，在这些天出现了0.5-1小时的HR变异性（周期性振荡），并且在这些天出现了，并且在胚胎开发中的振荡幅度增强了。4。IT由于胚胎的肺部流动而导致的外观和时间流动可能是由于胚胎的出现而被置于胚胎之前和后期，因此可以进行内部的记录。这是一个新发现，可能有助于在鸟类胚胎中投入肺气交换的原理机制。5。使用心电图，我们可以记录鸡胚胎在内部和外部poping期间的人力资源波动。发现人力资源变异性和不规则性及其时间过程在外部ppipping胚胎中特别独特。6。通过静脉注射各种自主药，研究了小鸡embylos产前发育过程中人力资源波动的自主神经对照。发现HR的瞬时减速是由副交感神经功能产生的。但是，交感神经功能与人力资源加速度的各种模式之间的关系尚不清楚，需要进一步研究。