Cognitive Neuropsychological Study for Learning Disability

学习障碍的认知神经心理学研究

• 批准号: 10670730
• 负责人: KOEDA Tatsuya
• 金额: $ 1.54万
• 依托单位: Tottori University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670730/
• 关键词: Learning Disability; Dyslexia; Functional MRI; Cognitive Neuropsychology; Developmental Disorder; 神経生理学; 脳波; コヒーレンス

【Aim】The aim of this study is to clarify the association between dyslexia and the brain dysfunction using functional MRI analysis.【Subjects and Method】Four dyslexic children and age-matched normal children were nominated. Ten sentences, which were contructed by 14 or 15 Japanese phonemic letters, as on-task and 10 meaningless figures as off-task were employed. MRI was scanned by EPI method using axial section. Statistical analysis (p<0.05 after Gaussian smoothing) was performed using MEDx soft ware.【Results】The second temporal gyrus in left hemisphere, which was correspond to Wernicke's area, was activated in normal controls. In dyslexia, two children showed the activation in left prefrontal gyrus, and two occipital lobe.【Discussion】We found the differences between normal and dyslexic children under the reading task. In dyslexia, two patterns of activation were observed. These results suggest that dyslexia is associated with brain dysfunction and their cognitive process might have several different patterns.

【目的】本研究旨在通过功能性MRI分析阐明阅读障碍与脑功能障碍之间的关系。【对象与方法】提名4名阅读障碍儿童和年龄匹配的正常儿童。使用由 14 或 15 个日语音素字母构成的 10 个句子作为任务中的句子，使用 10 个无意义的数字作为任务外的句子。 MRI 通过 EPI 方法使用轴向切片进行扫描。采用MEDx软件进行统计分析（高斯平滑后p<0.05）。【结果】正常对照组左半球第二颞回（韦尼克区）被激活。在阅读障碍中，两名儿童表现出左前额回和两个枕叶的激活。【讨论】我们发现正常儿童和阅读障碍儿童在阅读任务下的差异。在阅读障碍中，观察到两种激活模式。这些结果表明阅读障碍与大脑功能障碍有关，他们的认知过程可能有几种不同的模式。

项目成果

汐田まどか 小枝達也 他: "学習障害の診断と療育"小児科. 39・8. 921-929 (1998)

Madoka Shiota、Tatsuya Koeda 等：“学习障碍的诊断和治疗”儿科学 39・8（1998）。

小枝達也 二上哲志: "シンポジウム1.医学は学習障害児をどこまでとらえたか? 序論"脳と発達. 31・3. 26-27 (1999)

小枝达也和二上哲志：“研讨会 1. 医学在多大程度上考虑了学习障碍儿童？简介” 31・3 (1999)。

小枝達也: "学習障害児の育成上の課題"第25回日本医学会総会会誌. III. 270 (1999)

小枝达也：《学习障碍儿童的养育问题》第 25 届日本医学会会刊第 270 期（1999 年）。

汐田まどか 小枝達也: "小児神経学からみた子どもの精神症状"小児の精神と神経. 39・4. 287-293 (1999)

Madoka Shiota 和 Tatsuya Koeda：“从儿科神经病学角度看儿童的精神症状”《儿童精神病学和神经病学》39・4（1999）。

Koeda T, Terakawa S and Shiota M.: "Distribution i n Normal Subjects of Performance in Token test : a Basic Study for the Diagnosis of Learning Disabilities"No to Hattatsu. Vol.32, No.1. 25-28 (2000)

Koeda T、Terakawa S 和 Shiota M.：“令牌测试中正常受试者表现的分布：学习障碍诊断的基础研究”向 Hattatsu 说不。