Adaptive Bone Remodeling Under Mechanical Stimuli

在幼龄大鼠胫骨上施加几种不同波形的无创三点弯曲载荷，并用光镜对新形成的骨进行标记和观察，发现编织骨形成的位置依赖于载荷的波形。对各自波形载荷产生的应变与编织骨形成位置之间关系的研究表明，在产生动态压缩应变的表面上形成了大量的编织骨。通过CT图像分析和荧光骨标记观察尺骨截骨后犬桡骨的变化。观察发现，新骨的形成并不均匀，而是在前尺骨附近的骨膜上形成的。这说明这些区域处于动压应变作用下，而动压应变本身就是骨形成的有效刺激。这些动态压缩应变特定编织骨形成将说明骨重塑的适应性

Noninvasive three-point bending loads of several distinctive waveforms were applied onto the tibias of young growing rats, and newly formed bones were labeled and observed by light microscopy, The locations of the woven bone formation were shown to be dependent on the waveforms of loads. Examination of the relations between the strains generated by the loads of respective waveforms and the locations of the woven bone formation revealed that the significantly greater amounts of woven bones were formed on the surfaces where dynamic compressive strains were generated.Furthermore, canine radius after the osteotomy of the ulna was observed by CT image analyses and fluorescence bone labeling. The observation revealed that the new bone was formed not uniformly on the periosterium, but on the periosterium adjacent to the former ulna. This fact suggest those area are under the dynamic compressive strains, and the dynamic compressive strain alone is the effective stimuli for the bone formation.These dynamic compressive strain specific woven bone formation would give accounts of the adaptive nature of bone remodeling