Adaptive Bone Remodeling Under Mechanical Stimuli

机械刺激下的适应性骨重塑

• 批准号: 10680790
• 负责人: TAKAKUDA Kazuo
• 金额: $ 2.05万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10680790/
• 关键词: Biomechanics; Bone; Stress; Adaptation; Remodeling

Noninvasive three-point bending loads of several distinctive waveforms were applied onto the tibias of young growing rats, and newly formed bones were labeled and observed by light microscopy, The locations of the woven bone formation were shown to be dependent on the waveforms of loads. Examination of the relations between the strains generated by the loads of respective waveforms and the locations of the woven bone formation revealed that the significantly greater amounts of woven bones were formed on the surfaces where dynamic compressive strains were generated.Furthermore, canine radius after the osteotomy of the ulna was observed by CT image analyses and fluorescence bone labeling. The observation revealed that the new bone was formed not uniformly on the periosterium, but on the periosterium adjacent to the former ulna. This fact suggest those area are under the dynamic compressive strains, and the dynamic compressive strain alone is the effective stimuli for the bone formation.These dynamic compressive strain specific woven bone formation would give accounts of the adaptive nature of bone remodeling

将几种不同波形的非侵入性三点弯曲载荷施加到年轻生长大鼠的胫骨上，并通过光学显微镜标记和观察新形成的骨骼，显示编织骨形成的位置取决于载荷的波形。对各波形载荷产生的应变与编织骨形成位置之间关系的检查表明，在产生动态压缩应变的表面上形成了明显大量的编织骨。此外，通过CT图像分析和荧光骨标记观察尺骨截骨后的尖牙半径。观察发现，新骨并非均匀地形成在骨膜上，而是形成在与原尺骨相邻的骨膜上。这一事实表明这些区域处于动态压缩应变之下，并且动态压缩应变本身就是骨形成的有效刺激。这些动态压缩应变特定的编织骨形成将说明骨重塑的适应性性质

项目成果

T Kanaya, T Koyama, H Matsumoto, K Takakuda H Miyair: "Adaptive Bone Remodeling in canine radius after ulnar Osteotomy"Proceeding of the JSME 2000. 00-1-II. 231 (2000)

T Kanaya、T Koyama、H Matsumoto、K Takakuda H Miyair：“尺骨截骨术后犬齿半径的适应性骨重塑”JSME 2000 年论文集。00-1-II。

高久田 和夫: "骨の適応的リモデリング"顎顔面バイオメカニクス学会誌. 5. 83-84 (1999)

Kazuo Takakuda：“骨骼的适应性重塑”颌面生物力学学会杂志 5. 83-84 (1999)。

高久田和夫,松本裕子,宮入裕夫: "骨の適応的リモデリング"顎顔面バイオメカニクス学会雑誌. 5-1. 83-84 (1999)

Kazuo Takakuda、Yuko Matsumoto、Hiroo Miyairi：“骨的适应性重塑”颌面生物力学学会杂志 5-1（1999）。

Takakuda K.: "Mechanical Loading of Bone and Joints (Ed Takahashi HE), Springer"Adaptive Bone Remodeling under Mechanical Stimuli.. 131-138 (1999)

Takakuda K.：“骨骼和关节的机械负载（Ed Takahashi HE），Springer”机械刺激下的自适应骨骼重塑.. 131-138 (1999)

Kazuo Takakuda: "Experimental Study on Adaptive Bone Remodeling"Clinical Orthopaedics. 33. 963 (1998)

Kazuo Takakuda：“适应性骨重塑的实验研究”临床骨科。