Tissue Reconstruction Based on Adaptive Remodeling

基于自适应重塑的组织重建

• 批准号: 23300163
• 负责人: TAKAKUDA Kazuo
• 金额: $ 9.24万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23300163/
• 关键词: バイオメカニックス; 人工臓器工学; 生体物性

Number of patients suffering degenerative disorder of connective tissues is increasing as the aging of populations. For the treatment of such disorders, regenerative medicines of connective tissues were investigated in this project. They were (1) dental implant connecting to surrounding soft tissues (mimics of Sharpey fibers), (2) bone generation on the surface of bone tissue (artificially induced periosteal bone growth), and (3) anastomosing devices for small feeding vessels (technology for autogenous bone grafting). Achievement for respective theme are; (1) autologous anchorage of collagen fibers onto the mesh structures placed on the surface of implants were confirmed and firm fixation of soft tissues were realized, (2) bone generation in the artificially created space under the periosteum was realized with the combined usages of hydroxiapatite/collagen nano-composites, and (3) the miniature devices developed successfully anastomose vessels as small as 1 mm diameter.

随着人口老龄化，患有结缔组织退行性疾病的患者数量正在增加。为了治疗这些疾病，本项目研究了结缔组织再生药物。它们是（1）与周围软组织连接的牙种植体（模仿Sharpey纤维），（2）骨组织表面的骨生成（人工诱导骨膜骨生长），和（3）小供血血管的封闭装置（自体骨移植技术）。各自主题的成就;（1）证实胶原纤维自体锚定到放置在植入物表面的网状结构上，并实现软组织的牢固固定，（2）结合使用羟基磷灰石/胶原纳米复合材料，实现在骨膜下人工创造的空间中的骨生成，（3）成功研制了直径为1 mm的血管微导管。

项目成果

Reconstruction of small diameter arteries using decellularized vascular scaffolds.

• DOI: 10.11480/610105
• 发表时间: 2014-03
• 期刊: Journal of medical and dental sciences
• 作者: Yuki Nagaoka;H. Yamada;Tsuyoshi Kimura;A. Kishida;T. Fujisato;K. Takakuda

人工歯根への軟組織付着の試み

尝试将软组织附着到人造牙根上

• 发表时间: 2013
• 作者: Furuse T.;Yamada I.;Kushida T.;Masuya H.;Ikuo Miura.;Kaneda H.;Kobayashi K.;Wada Y.,Yuasa S.;Wakana S;黒木 修司;高谷節雄;高久田和夫
• 通讯作者: 高久田和夫

Bone Forming Capability Around Novel Subperiosteal Anchorage Device for Orthodontic Treatment

用于正畸治疗的新型骨膜下锚固装置周围的骨形成能力

• 发表时间: 2011
• 作者: Uezono M;Takakuda K;Suzuki S;Moriyama K
• 通讯作者: Moriyama K

Laser-Perforated Porous Nonwoven Chitosan Nerve Conduit

激光穿孔多孔非织造壳聚糖神经导管

• DOI: 10.1299/jbse.8.139
• 发表时间: 2013
• 期刊: Journal of Biomechanical Science and Engineering
• 作者: Rodotheou P;Wang W;Itoh S;Okazaki M;Takakuda K
• 通讯作者: Takakuda K

The Coating for Enhanced Osseointegration of Subperiosteal Anchorage Device.

增强骨膜下锚固装置骨整合的涂层。

• 发表时间: 2012
• 作者: 東森一晃;横井喜充;星野真弘;上園将慶;上園将慶;上園将慶;上園将慶
• 通讯作者: 上園将慶