Tissue Reconstruction Based on Adaptive Remodeling

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Number of patients suffering degenerative disorder of connective tissues is increasing as the aging of populations. For the treatment of such disorders, regenerative medicines of connective tissues were investigated in this project. They were (1) dental implant connecting to surrounding soft tissues (mimics of Sharpey fibers), (2) bone generation on the surface of bone tissue (artificially induced periosteal bone growth), and (3) anastomosing devices for small feeding vessels (technology for autogenous bone grafting). Achievement for respective theme are; (1) autologous anchorage of collagen fibers onto the mesh structures placed on the surface of implants were confirmed and firm fixation of soft tissues were realized, (2) bone generation in the artificially created space under the periosteum was realized with the combined usages of hydroxiapatite/collagen nano-composites, and (3) the miniature devices developed successfully anastomose vessels as small as 1 mm diameter.