Tissue Regeneration with 3D Devices of Optimum Biomechanical Design

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Fundamental investigations were performed to establish the design principles for the optimum mechanical characteristics of the tissue-regeneration devices. Specifically, the scaffold structures, the vascularizable structures, and the protective structures were developed for the regeneration of peripheral nerves, ligaments, periodontal tissues, and small caliber blood vessels. Experimental devices were created with the usages of bioabsorbable polymers as PLLA and their performances were examined in animal experiments.