Bone Regeneration with the use of Tissue Engineering

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We investigated new bioabsorbable inorganic/organic composite materials, that are b-TCP/PLGC for the GBR membrane of which matrix is biodegradable polymer (PLGC) and fillers are beta-tricalcium phosphate (b-TCP). Experimental animals were male Beagle and Mongrel dogs of ca 1 year old, and male Japanese white rabbits of body weight ca 2.5kg and male SD rats of 8 to 10 weeks old. For the b-TCP/PLGC membranes, various experimental of GBR treatments were examined. The one was for mandibular bones. The bone defects of 1Ox10x1Omm were made and covered with the bioabsorbable membranes. The bone formations within the bone defects were examined with X-rays in every 4 weeks, and it was shown that the defects were filled with bone tissues after 12 weeks. The experimental bone defects of 20mm length in canine tibia were similarly treated. The defects were filled with bone tissues except central cartilage tissues of several mm lengths. The canine skulls with holes of 10mm diameter were similarly treated and bone formations were observed. No bone formations were observed in control specimens in every case. The transplantation of periosteal membrane were tried with the use of the bioabsorbable membrane and found that they enhance the early bone formation significantly.