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Recovery of motor function by noninvasive stimulation of the human brain.

通过对人脑的无创刺激来恢复运动功能。

基本信息

批准号：
10838039
负责人：
IZUMI Shin-ichi
金额：
$ 2.24万
依托单位：
Tokai University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

项目摘要

1) We established EEG monitoring system during TMS for patients with risk of epilepsy. First, we determined the changes and responses in the electroencephalogram (EEG) induced by transcranial magnetic stimulation (TMS) of the scalp of stroke patients. To reduce stimulus artifacts, we created a circuit that blocked the input for 150 msec after stimulation. No epileptiform afterdischarges or sharp wave potentials were observed. After this preliminary study, we revised the artifact-reducing circuit so as to record EEG 50 msec after stimulation.2) We investigated facilitation in voluntary movement, and demonstrated that facilitation occurs during voluntary contraction of antagonist or other heteronymous muscles. It also was found that the degree of facilitation induced by a heteronymous muscle contraction differed between individual muscles, and between dominant and nondominant forearm muscles.3) We investigated short-term effects of TMS over the frontal lobe on cognitive function such as … More frontal lobe function, attention, and memory, and EEG of healthy subjects. Then, we concluded that TMS has no adverse effects on cognitive and electrophysiologic function.4) One stroke patient (48 years of age, male, left putaminal hemorrhage, right hemiplegia for 3 years and 4 months) provided his informed consent to participate in this study. TMS (0.1 Hz, 100 stimuli) were delivered over the motor cortex every week for 3 months. The subject was instructed to make efforts of contracting the target muscle (facilitation) when stimulated. Before stimulation the subject could flex fingers (mass flexion), and extend the little finger less than 5 degrees (Brunnstrom stage 3). After stimulation the subject could extend all the fingers and thumb except the index finger, and move the little finger separately. TMS could not evoke motor responses during the first three sessions. Motor responses evoked by TMS appeared at the 4th session, and amplitudes of the motor evoked potentials increased gradually. No epileptiform afterdischarges or sharp wave potentials were observed. In the future study effectiveness of TMS will be investigated in a rondomized control study and an indication of TMS for treatment of hemiplegia will be suggested. Less

1)建立了癫痫高危患者TMS期间的脑电监测系统。首先，我们测定了中风患者头皮经颅磁刺激(TMS)引起的脑电(EEG)的变化和反应。为了减少刺激伪影，我们创建了一个电路，在刺激后阻止输入150毫秒。未观察到癫痫样后放电或尖波电位。在这项初步研究之后，我们修改了伪迹减少回路，以便记录刺激后50毫秒的脑电。2)我们研究了自主运动中的易化，证明易化发生在拮抗者或其他异名肌肉的自愿收缩过程中。我们还发现，异名肌肉收缩引起的易化程度在个体肌肉之间以及优势和非优势前臂肌肉之间存在差异。3)我们研究了额叶TMS对认知功能(如…)的短期影响健康受试者额叶功能、注意力、记忆力和脑电的增加。4)1例卒中患者(48岁，男性，左侧壳核出血，右侧偏瘫3年4个月)知情同意参与本研究。TMS(0.1赫兹，100个刺激)每周通过运动皮质进行，持续3个月。受试者被指示在刺激时努力收缩目标肌肉(易化)。刺激前，受试者可以屈指(身体屈曲)，小指伸展不到5度(Brunnstrom阶段3)。刺激后，受试者可以伸展除食指以外的所有手指和拇指，并分别移动小指。在前三次治疗中，TMS不能引起运动反应。TMS诱发的运动反应在第4节开始出现，运动诱发电位的波幅逐渐增大。未观察到癫痫样后放电或尖波电位。在未来的研究中，TMS的有效性将在随机对照研究中进行调查，并将提出TMS治疗偏瘫的适应证。较少