Study of the two kinds of mechanism of autonomic nerve system controlling thoracic and abdominal visceral organs

自主神经系统控制胸腹部内脏器官的两种机制研究

• 批准号: 12670008
• 负责人: SATO Kenji
• 金额: $ 2.11万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670008/
• 关键词: autonomic nerve system; sympathetic nerve; cardiac innervation; blood pressure; cardiac nerve; greater splanchnic nerve; 心臓の2重支配; 血圧; 自律神経再生; 神経再建; 脊髄中枢; 比較解剖

This study was undertaken to explore the peripheral signal controlling blood pressure reactions with contraction of the ventricular myocardium in the dog.Our results indicate the presence of the two kinds of mechanisms controlling blood pressure of the left ventricular contraction; one is the direct innervation system to the myocardium , and the other the hormonal system consisting of the greater splanchnic nerves.1) Responses of canine myocardium to electrical stimulation of cardiac nerves from the upper thoracic sympathetic trunk, caused contraction of the left ventricle and blood pressure elevation of the femoral artery. Transaction of all peripheral cardiac nerve pathway to the heart, completely blocked these response.2) The other sympathetic nerves systems reaching the adrenal medulla via the lower thoracic sympathetic chain and the greater splanchnic nerves may have a possibility of affecting cardiac contraction through hormonal system. Catecholamines secreted from the adrenal medulla can elicit similar systemic reactions, such as marked elevation of blood pressure,tachycaedia.

本研究旨在探讨外周信号对犬血压反应与心室心肌收缩的控制作用。我们的结果表明存在两种控制左心室收缩血压的机制；一个是直接支配心肌的神经系统，另一个是由大内脏神经组成的激素系统。1)犬心肌对来自胸上交感干的心神经电刺激的反应，引起左心室收缩和股动脉血压升高。交易的所有外周心神经通路到心脏，完全阻断了这些反应。2)经下胸椎交感神经链到达肾上腺髓质的其他交感神经系统和大内脏神经可能通过激素系统影响心脏收缩。肾上腺髓质分泌的儿茶酚胺可引起类似的全身反应，如血压明显升高、心动过速。

项目成果

Kazunori, kihara. Et al.: "Reconstruction of the, canine pelvic nerve and Its Application to Bladder Transplantation"Nurourol. Urodyn.. 20. 187-196 (2001)

和则、木原。

Kihara K, Sato K, Kageyama, Inoue Y.: "Reconstraction of the canine pelbic nerne and its application to bladder transplantation"Neurourol. Urodyram.. 20. 187-196 (2001)

Kihara K、Sato K、Kageyama、Inoue Y.：“犬骨盆神经的重建及其在膀胱移植中的应用”Neurourol。

川島友和, 佐藤健次: "心臓を支配する交感神経系の形態学的解析"自律神経. 37. 521-531 (2000)

Tomokazu Kawashima、Kenji Sato：“控制心脏的交感神经系统的形态分析”自主神经系统。37. 521-531 (2000)。

木原和徳,佐藤健次: "骨盤手術と骨盤の自律神経の再建"排尿障害プラクティス. 57. 305-312 (2000)

Kazunori Kihara、Kenji Sato：“盆腔手术和盆腔自主神经重建”《泌尿疾病实践》57. 305-312 (2000)。

Yonese, J. et al.: "Sympathetic efferent pathways projecting to the prostate in the dog"Prostate. 44. 225-232 (2000)

Yonese, J. 等人：“投射到狗前列腺的交感传出通路”前列腺。