Neural representation of attention in associative areas in the chick telencephalon

雏鸡端脑关联区域注意力的神经表征

• 批准号: 13640677
• 负责人: MATSUSHIMA Toshiya
• 金额: $ 2.24万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13640677/
• 关键词: Birds; Brain; Mind; Evolution; Cognition; Memory; Anticipation; Basal ganglion; 行動; インプリンティング; シナプス; 強化学習

Chicks of precocial birds have highly developed cognitive behaviors immediately after hatching. Taking advantage of this nature, we have accomplished a series of experiments upon the issue of memory formation and behavioral execution, particular on the "attention and consciousness" in birds. Comprehensive studies using behavioral and brain lesion methods, as well as electrophysiological studies in brain slices and single neuron recording in freely behaving chicks, resulted in the following findings. It is suggested that the attention is represented in a highly distributed manner in many areas in the chick brain.(1) <Basal ganglia : neural correlates of memory-based anticipation and their functional roles>___-A behavioral task was developed in which food-reinforcement color discrimination was associated with the waiting time in 1-2 weeks old domestic chicks. A localized chemical lesions to posterior par of bilateral basal ganglia (medial striatum) caused an impulsive choice in the concu … More rrent choice test, with the choice based on the anticipated quantity of associated reward remained intact. Behavioral execution based on the temporal proximity of the anticipated reward was specifically impaired. So long as the future gain is represented in the medial striatum, chicks could patiently suppress the impulsive option toward immediate but small gain, thus making the long-term benefits to be maximized.(2) <Analogues of amygdala-orbitofrontal cortex system : neural coding of reference memory of associations and working memory of sound sources>___-Single neuron recording from archistriatum of chicks reveals two major populations of neurons that coded (1) reference memory for color-reward associations and (2) working memory for the location of sound cues.(3) <Hippocampus : involvement in the formation of spatial memory>___-Localized lesions to the bilateral hippocampus selectively impaired the acquisition of spatial memory, while the color discrimination remained intact.(4) <Cerebellum : Non-genomic action of progesterone>___-Results of whole cell recording from Purkinje neurons in the chick cerebellum suggested that application of exogenous progesterone enhances the excitatory relay by the granule cells. Less

孵化后，早熟鸟类的小鸡立即具有高度发展的认知行为。利用这种性质，我们在记忆形成和行为执行问题上，特别是在鸟类中的“注意力和意识”上进行了一系列实验。使用行为和脑部病变方法的全面研究，以及在自由行为的雏鸡中进行的脑切片和单个神经元记录的电生理研究，导致了以下发现。建议在雏鸡大脑的许多领域以高度分布的方式表示注意力。（1）<基础神经节：基于内存的预期及其功能角色的神经相关性> ___-开发了一种行为任务，其中开发了食物增强的颜色歧视与1-2周的等待时间相关联。双侧基底神经节（内侧纹状体）的局部化学病变在企业中引起了冲动的选择……更加选择的选择测试，基于预期的相关奖励数量的选择仍然完好无损。基于预期奖励的暂时接近性的行为执行特别受损。只要在媒体纹状体中代表未来的收益，小鸡就可以耐心地抑制冲动的选择，但要立即获得但很小的收益，从而使长期的收益最大化。（2）<杏仁核 - 轨道性皮质系统的类似物的类似物：与单个Neuron的库存> ____-neuron的神经记录的神经关注的神经关注型的神经摄影效果> __-_-neuron的作用。编码的神经元（1）引用色彩奖励关联的参考记忆以及（2）声音提示位置的工作记忆。（3）<海马<海马：参与空间记忆的形成> ____-局部病变局部病变，对双侧海马有选择性地损害了空间记忆的障碍，同时<cation not-non-not-non-gliment <can not-cantection。孕激素> ___-鸡小脑中浦肯野神经元的全细胞记录结果表明，外源孕酮的应用增强了颗粒细胞的兴奋性继电器。较少的

项目成果

Hayashi, I., Ono, Y., Matsushima, T.: "Visual cues for suppressing the isolation-induced distress calls in newly hatched quail chicks"Zoological Science. 18. 1065-1071 (2001)

Hayashi, I.、Ono, Y.、Matsushima, T.：“抑制新孵出的鹌鹑雏鸟因孤立而引起的求救呼叫的视觉线索”《动物学科学》。

Matsushima, T., Izawa E.-I., Aoki, N., Yanagihara, S.: "The mind through chick eyes : memory, cognition and anticipation"Zoological Science. (in press). (2003)

Matsushima, T.、Izawa E.-I.、Aoki, N.、Yanagihara, S.：“通过小鸡眼睛观察心灵：记忆、认知和预期”动物学。

Matsushima, T., Izawa, E.-I., and Yanagihara, S.: "D1-receptor dependent synaptic potentiation in the basal ganglia pf quail chick"Neuro Report. vol.12. 2831-2837 (2001)

Matsushima, T.、Izawa, E.-I. 和 Yanagihara, S.：“鹌鹑雏鸡基底神经节中 D1 受体依赖性突触增强”神经报告。

Hayashi, I., Ono, Y., and Matsushima, T.: "Visual cues for suppressing the isolation-induced distress calls in newly hatched quail chicks"Zoological Science. vol.18. 1065-1071 (2001)

Hayashi, I.、Ono, Y. 和 Matsushima, T.：“抑制新孵出的鹌鹑雏鸟因孤立而引起的求救呼叫的视觉线索”《动物学科学》。

Aoki N., Izawa, E.-I., Yanagihara, S., and Matsushima, T.: "Neural correlates of memorized associations and cued movements in archistriatum of the domestic chick"European Journal of Neuroscience. (in press). (2003)

Aoki N.、Izawa, E.-I.、Yanagihara, S. 和 Matsushima, T.：“家养小鸡古纹状体中记忆关联和提示运动的神经关联”《欧洲神经科学杂志》。