Genetic and Neural Basis of Imprinting in Quail Chicks

鹌鹑雏鸡印记的遗传和神经基础

• 批准号: 10044202
• 负责人: MATSUSHIMA Toshiya
• 金额: $ 3.01万
• 依托单位: NAGOYA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10044202/
• 关键词: Brain; Behavior; Memory; Imprinting; Basal ganglion; Synapse; Reinforcement learning; Birds; 長期増強; ドーパミン

In this project, we studied cognitive functions and the underlying brain mechanisms of memory formation and behavioral control in newly hatched quail/domestic chicks. A series of experimental researches, ranging from behavioral analyses, through, neurophysiological studies of synapses and neuronal properties such as long-term potentiation/depression, molecular mechanisms like immediate early gene expression(c-fos and ZENK), toward the system neuroscience with single unit recording from freely behaving chicks. These studies were accomplished in a close joint activities between Hungarian and Japanese attendant scientists.Following researches were performed.1. Behavioral studies : Development of novel learning tasks and analysis of the memory contents.2. Physiological studies of the elementary memory process : Synaptic long-term potentiation and immediate early genes.3. System neuroscience studies of the cellular expression of memoryThese studies gave us an idea that birds, who have diverged from the evolutionary path from mammals several hundreds of million years ago, are endowed with basically identical cognitive process as mammals(even primates)possess. Comparative Cognitive Brain Science serves the unique strategy for elucidating the origin of "intelligence."

本研究以鹌鹑/家鸡为研究对象，探讨了其认知功能以及记忆形成和行为控制的脑机制。一系列的实验研究，从行为分析，到突触和神经元特性的神经生理学研究，如长时程增强/抑制，分子机制，如立即早期基因表达（c-fos和ZENK），到系统神经科学，从自由行为的鸡的单单位记录。这些研究是在匈牙利和日本随行科学家的密切合作下完成的。行为研究：新学习任务的开发和记忆内容的分析.基础记忆过程的生理学研究：突触长时程增强和即刻早期基因.记忆细胞表达的系统神经科学研究这些研究让我们想到，数亿年前从哺乳动物进化道路上偏离的鸟类，具有与哺乳动物（甚至灵长类动物）基本相同的认知过程。比较认知脑科学是阐释“智力”起源的独特策略。"

项目成果

Ukena K.,Kohchi C.and Tsutsui K.: "Expression and activity of 3β-hydroxysteroid dehydrogenase/Δ^5-Δ^4-isomerase in the rat Purkinje neuron during neonatal life."Endocrinology. 140. 805-813 (1999)

Ukena K.、Kohchi C. 和 Tsutsui K.：“新生儿期大鼠浦肯野神经元中 3β-羟基类固醇脱氢酶/Δ^5-Δ^4-异构酶的表达和活性。” 140. 805-813 (1999) ）

Aoki,M.,Izawa E.-I.,Koga,K.,Yanagihara,S.,and Matsushima,T.: "Accurate visual memory of colors in controlling the pecking behavior of quail chicks."Zoological Science. 17. 1053-1059 (2000)

Aoki,M.、Izawa E.-I.、Koga,K.、Yanagihara,S. 和 Matsushima,T.：“控制鹌鹑雏鸟啄食行为的颜色的准确视觉记忆。”动物学。

Mezey S,Szekely AD,Bourne RC,Kabai P,Csillag A: "Changes in binding to muscarinic and nicotinic cholinergic receptors in the chick telencephalon,following passive avoidance learning."Neurosci.Lett.. 270. 75-78 (1999)

Mezey S、Szekely AD、Bourne RC、Kabai P、Csillag A：“被动回避学习后，小鸡端脑中毒蕈碱和烟碱胆碱能受体的结合发生变化。”Neurosci.Lett.. 270. 75-78 (1999)

Yanagihara,S.,Izawa,E-I.,Koga,K.,and Matsushima,T.: "Reward-related neuronal activities in basal ganglia of domestic chicks."NeuroReport. (in press). (2001)

Yanagihara, S.、Izawa, E-I.、Koga, K. 和 Matsushima, T.：“家养小鸡基底神经节中与奖励相关的神经元活动。”NeuroReport。

Yanagihara,S.,Izawa,E.,and Matsushima,T.: "Single unit activity in lobus parolfactorius (LPO: basal ganglia) of freely-behaving 2-day old domestic chicks during and immediately after one-trial passive avoidance training."Society for Neuroscience(Abstract)

Yanagihara,S.、Izawa,E. 和 Matsushima,T.：“在一次试验性被动回避训练期间和训练结束后，行为自由的 2 日龄家养雏鸡的嗅叶（LPO：基底神经节）中的单个单位活动。