Relocation of Memory Traces for "Imprinting" and Basal Ganglia - Mesencephalic Dopamine System

“印记”记忆痕迹的重新定位和基底神经节 - 中脑多巴胺系统

• 批准号: 11680785
• 负责人: MATSUSHIMA Toshiya
• 金额: $ 2.37万
• 依托单位: NAGOYA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11680785/
• 关键词: Brain; Behavior; Memory; Imprinting; Basal ganglion; Synapse; Reinforcement learning; Birds; 長期増強

In this project, we studied cognitive functions and the underlying brain mechanisms of memory formation and behavioral control in newly hatched quail/domestic chicks. A series of experimental researches, ranging from behavioral analyses, throught neurophysiological studies of synapses and neuronal properties such as long-term potentiation/depression, molecular mechanisms like immediate early gene expression (c-fos and ZENK), toward the system neuroscience with single unit recording from freely behaving chicks. These studies were accomplished in a close joint activities between Hungarian and Japanese attendant scientists.Following researches were performed.1. Behavioral studies : Development of novel learning tasks and analysis of the memory contents.2. Physiological studies of the elementary memory process : Synaptic long-term potentiation and immediate early genes.3. System neuroscience studies of the cellular expression of memoryThese studies gave us an idea that birds, who have diverged from the evolutionary path from mammals several hundreds of million years ago, are endowed with basically identical cognitive process as mammals (even primates) possess. Comparative Cognitive Brain Science serves the unique strategy for elucidating the origin of "intelligence."

在本项目中，我们研究了新孵鹌鹑/家鸡的认知功能及其记忆形成和行为控制的脑机制。一系列的实验研究，从行为分析，通过突触和神经元特性的神经生理学研究，如长期增强/抑制，分子机制，如即时早期基因表达（c-fos和ZENK），到系统神经科学与单单位记录自由行为的小鸡。这些研究是在匈牙利和日本随行科学家的密切联合活动下完成的。进行了以下研究：行为研究：开发新的学习任务和分析记忆内容。初级记忆过程的生理学研究：突触长期增强和即时早期基因。记忆细胞表达的系统神经科学研究这些研究让我们认识到，数亿年前从哺乳动物的进化路径中分离出来的鸟类，具有与哺乳动物（甚至灵长类动物）基本相同的认知过程。比较认知脑科学为阐明“智力”的起源提供了独特的策略。

项目成果

Aoki,M.,Izawa E.-I.,Koga,K.,Yanagihara,S.,and Matsushima,T.: "Accurate visual memory of colors in controlling the pecking behavior of quail chicks."Zoological Science. 17. 1053-1059 (2000)

Aoki,M.、Izawa E.-I.、Koga,K.、Yanagihara,S. 和 Matsushima,T.：“控制鹌鹑雏鸟啄食行为的颜色的准确视觉记忆。”动物学。

Fujiwara,A.,Ohzone,Y,Naito,J.: "The Developmental study on lamination of the optic tectum in relation to the retinotectal projection in chicks and chick embryos."J.Vet.Med.Sci.. 62. 511-516 (2000)

Fujiwara,A.,Ohzone,Y,Naito,J.：“视顶盖层压与小鸡和鸡胚胎视网膜顶盖投射相关的发育研究。”J.Vet.Med.Sci.. 62. 511-

Yazaki, Y., Matsushima, T., and Aoki, K.: "Testosterone modulates stimulation-induced calling behavior in Japanese quails."Journal of Comparative Physiology A. 184. 13-19 (1999)

Yazaki, Y.、Matsushima, T. 和 Aoki, K.：“睾酮调节日本鹌鹑刺激诱导的呼叫行为。”比较生理学杂志 A. 184. 13-19 (1999)

Chen, Y., Naito, J.: "Retinal specialization of ganglion cell layer of the chick retina."J.Vet.Med.Sci.. 62. 53-57 (2000)

Chen, Y., Naito, J.：“小鸡视网膜神经节细胞层的视网膜特化。”J.Vet.Med.Sci.. 62. 53-57 (2000)

Ishikawa,Y.,Koga,K.,and Matsushima T.: "Slowly developing potentiation in goldfish retino-tectal synapses is masked by prior stimulation ; an in vitro study."Comparative Biochemistry and Physiology A. 124. 81-88 (1999)

Ishikawa, Y.、Koga, K. 和 Matsushima T.：“金鱼视网膜-顶盖突触中缓慢发展的增强被先前的刺激所掩盖；一项体外研究。”比较生物化学和生理学 A. 124. 81-88 (1999)