DEVELOPMENT OF THE LASER ULTRASONIC MICROMANIPULATOR

激光超声波微操作器的研制

• 批准号: 13650286
• 负责人: TAKEUCHI Masao
• 金额: $ 2.62万
• 依托单位: Tamagawa university
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13650286/
• 关键词: MNIPULATION; SMALL PARTICLE; RADIATION FORCE; LIQUID DROPLET; ULTRASONICS; LASER; 板波

Noncontact and nondestructive techniques for manipulation, such as transportation, trapping, and separation of micron-sized particles in liquid, are currently of considerable interest in areas of biotechnology, micromachining and microfuidics. Previously we have developed a new laser ultrasonic micromanipulator (LUMM) in which the acoustic radiation force and optical radiation force are both used as complementary noncontact forces. In this study, we have studied a high performance LUMM using a graphical user interface (GUI) on a Windows PC and the possibility of the liquid droplet to manipulation. This study was carried out for 2 years from April, 2001 by March, 2002. The following results and prospects were obtained.1) For the purpose of the performance enhancement of the experimental LUMM, capturing of the microscope image and GPIB control of the mechanical stage using GUI on Windows 98 in a PC were constructed successfully. However, the GPIB control of ultrasonic power and laser pow … More er became future problem.2) Using UV curing adhesive technology noticed in the electronic field recently, the wedge transducer of the small shape as ultrasonic source of the ultrasonic wave manipulation was produced experimentally. At the 5.48MHz operating frequency, the good characteristic of minimum insertion loss of 25.3dB and 3dB bandwidth of 9% was obtained.3) The experiment of trapping only the specific microns-sized particle by the removal of unnecessary particles using the wedge transducer from large number of particle quickly was carried out successfully. It is future problem to increase the operating frequency of the wedge transducer in order to reduce the electrical input power to the transducer.4) Recently, various processes such as transport and reaction, separation, purification, detection that are an element of the chemical process are integrated on glass and plastic substrate of several centimeter sizes are noticed, and so called Lab-on-a-Chip (LOC). It is indispensable to develop microfluidic technology which manipulates liquid droplet of a very small quantity (0.5μl-60μl) without requiring complicated pump and tube in order to realize LOG. Then, the manipulation of the droplet using plate wave (Lamb wave) of the 6MHz was tested assuming the integration to laser ultrasonic wave micromanipulator (LUMM). The result showed that the manipulation was possible.The part of these results was presented in the Inst. of Electrical Engineers of Japan 32nd EM symposium. The unpublished results will be presented in near future. The research will be continued on the basis of the result obtained through this study. Less

非接触和非破坏性的操作技术，如液体中微米级颗粒的输送、捕获和分离，目前在生物技术、微机械加工和微流体领域引起了相当大的兴趣。在此之前，我们已经开发了一种新的激光超声显微操作器（LUMM），其中声辐射力和光辐射力都被用作互补的非接触力。在这项研究中，我们已经研究了一个高性能的LUMM使用图形用户界面（GUI）在Windows PC和液滴的可能性进行操作。本研究从2001年4月至2002年3月进行了为期2年的研究。1）为了提高实验用LUMM的性能，在PC机上成功实现了显微镜图像采集和机械工作台的GPIB控制。然而，GPIB控制的超声功率和激光功率 ...更多信息 2）采用近年来在电子学领域引起关注的紫外光固化粘接技术，实验制作了作为超声波操纵超声源的小型楔形换能器。在5.48MHz的工作频率下，获得了最小插入损耗25.3dB、3dB带宽9%的良好特性。3）成功地进行了利用楔形换能器从大量颗粒中快速去除多余颗粒，仅捕获特定微米级颗粒的实验。提高楔形换能器的工作频率以降低换能器的电输入功率是未来的问题。4）最近，注意到作为化学过程的元素的各种过程（例如，传输和反应、分离、纯化、检测）被集成在几厘米大小的玻璃和塑料基板上，并且被称为芯片实验室（Lab-on-a-Chip，简称PLD）。为了实现微流控，发展微流控技术是必不可少的。微流控技术不需要复杂的泵和管，就可以操纵非常少量的液滴（0.5μl-60μl）。然后，假设集成到激光超声波显微操纵器（LUMM），测试使用6 MHz的板波（兰姆波）的液滴操纵。结果表明，这种操纵是可能的，其中一部分结果已在日本电机工程师学会第32届电磁研讨会上发表。未发表的结果将在不久的将来公布。将在本研究结果的基础上继续进行研究。少

项目成果

竹内 正男: "超音波マイクロマニピュレーション"精密工学会誌. 68巻11号. 1398-1401 (2002)

Masao Takeuchi：“超声波显微操作”日本精密工程学会杂志，第 68 卷，第 11 期。1398-1401 (2002)