No Invasive Methods For Cell Proliferation Activity Using Superconduction Quantum Interference Device

2001年，我们尝试用超导量子干涉仪测量电磁场随细胞增殖的变化。大量的噪声和基线漂移干扰了微电磁场的检测，由于空气循环系统保持细胞增殖的最佳温度，使检测条件变差。因此，我们花了很长的时间来获得良好的条件，以检测随着细胞增殖的微电磁场的变化。然而，我们无法获得该测试系统的最佳条件。第二年，我们尝试在室温下测量电磁场随细胞增殖的变化。降低了噪声和基线偏移。然而，我们没有发现显著的变化。由于SQUID的单通道探测器无法用于本课题的研究，我们申请使用多通道探测器进行脑活动的研究。我们还将继续研究骨痂形成过程中骨组织的阻抗，以检测组织水平的活动。我们用兔胫骨延长骨痂。等待时间为1周，延长率为0.5mm，每日2次。延长组织的阻抗值随愈伤组织的成熟而增大。阻抗为5.41 ^^+__- 1.75 KΩ。正常骨痂的阻抗值可作为与恶性骨肿瘤组织进行比较的有用数据

We tried to measure a electoromagnetic field changes with cell proliferation using Superconduction Quantum Interference Device in 2001. A lot of noise and base line shift made disturbance of detection of the micro electromagnetic field changes, becouse air circulating system to keep optimal temperature for cell proliferation made the test condition worse. Therefore, we took a long time to get the good condition in order to detect the micro electoromagnetic field changes with cell proliferation. However, we could not get the optimal conditions for this test system. Next year we tried to measure the electlomagnetic field changes with cell proliferation under room temperature. The noise and base line shift was reduced. However, we could not detect remarkable changes. Unfortunately, mono channel censer of SQUID could not be available to our research, then we applied to use the multi channel censers for brain activity. Now we will try to calibrate the electromagnetic fields for our study in near futureWe also continued to research for the impedance of bone tissue in the process of callus formation in order to detect tissue level activity. We used lengthend callus of tibiae in rabbits. The waiting period was 1 week and the lengthening rate was 0.5mm twice daily. The impedance values of lengthened tissue increased with the callus maturation. Impedance was 5.41 ^^+__- 1.75 KΩ. It was useful data as normal callus impedance in order to compare to malignant bone tumor tissue