Signal transduction of GPI-anchored proteins in lipid rafts

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The mechanism of signal transduction by GPI-anchored neural cell adhesion molecules is obscure, because GPI-anchored proteins have no transmembrane domains. Recent studies suggest dynamic clustering of glycosphingolipids (lipid rafts) function as platforms for attachment of GPI-anchored proteins, src-family kinases during signal transduction. In this research project, I pursued clarifying mechanism of signal transduction by GPI-anchored neural cell adhesion molecules.I previously reported that GPI-anchored neural cell adhesion molecule TAG-1 transduces signal via src-family kinase Lyn in lipid rafts of rat primary cerebellar cultures. In this year, I found that phosphacan, TAG-1 ligand, induces signal transduction in lipis rafts via src-family kinase Lyn and has repulsive effects on rat primary cerebellar cultures.