Development of Biomedical Polymeric Composite Materials with Functional Gradient Based on Biodegradable Polymers and Characterization

基于可生物降解聚合物的功能梯度生物医用高分子复合材料的研制及表征

• 批准号: 14208104
• 负责人: INOUE Yoshio
• 金额: $ 17.39万
• 依托单位: Tokyo Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14208104/
• 关键词: Biomedical Polymer; Polymer Blend; Functional Gradient Material; Biodegradable Plastic; Chitin; Poly(vinyl alcohol); Poly(ethyiene oxide); 組成傾斜材料; 高分子複合材料; 生分解性高分子; 医用高分子材; ポリエステル; ポリ(ε-カプロラクトン); キトサン

Recently, naturally inspired functional gradient materials have attracted much attention as a field of material science due to their excellent properties. In this research, several methodologies to generate the compositional and functional gradient structures in the polymeric composite materials have been developed and characterized their structures and properties.A method for quantitative analysis of the compositional distribution along the cross-section in the polymeric gradient films by FT-IR microspectroscopy was developed and it was applied to the biodegradable and biocompatible poly(ethylene oxide)/poly(3-hydroxybutyrate) blend films with compositional gradient fabricated by compression molding or solution diffusion methods. A continuous compositional gradient structure was successfully created by using a method of interdiffusion across the interface between poly(butylene succinate) and poly(ethylene oxide) layers at a temperature above the melting points of both component polymers. Further, a biodegradable immiscible poly(butylenes adipate-co-butylene terephthalate)/poly(ethylene oxide) polymer blend film with compositional gradient in the film thickness direction was successfully prepared in the presence of a low molecular weight compound diphenol as a miscibilityenhancing agent.

近年来，自然启发的功能梯度材料因其优异的性能而备受材料科学领域的关注。在这项研究中，开发了几种在聚合物复合材料中生成成分和功能梯度结构的方法，并表征了它们的结构和性能。开发了一种利用傅立叶变换红外显微光谱法定量分析聚合物梯度膜沿横截面的成分分布的方法，并将其应用于可生物降解和生物相容性聚乙烯 通过压缩成型或溶液扩散方法制备具有成分梯度的聚(3-羟基丁酸酯)/聚(3-羟基丁酸酯)共混薄膜。在高于两种组分聚合物熔点的温度下，通过使用跨聚丁二酸丁二醇酯和聚环氧乙烷层之间的界面相互扩散的方法，成功地创建了连续的组成梯度结构。此外，在低分子量化合物联苯酚作为混溶增强剂的存在下，成功制备了在膜厚度方向上具有组成梯度的可生物降解的不混溶的聚（己二酸丁二醇酯-共聚对苯二甲酸丁二醇酯）/聚环氧乙烷聚合物共混膜。

项目成果

Effect of chemical compositional distribution on solid-state structures and properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate)

• DOI: 10.1016/j.polymer.2004.01.025
• 发表时间: 2004-03
• 期刊: Polymer
• 影响因子: 4.6
• 作者: N. Yoshie;M. Saito;Y. Inoue

Nanoscale-Confined and Fractional Crystallization of Poly(ethylene oxide) in the Interlamellar Region of Poly(butylenes succinate)

聚环氧乙烷在聚丁二酸丁二醇酯层间区域的纳米级限制和分级结晶

• 发表时间: 2004
• 期刊: Macromolecules Vol.37, No.9
• 作者: Yong He;Bo Zhu;Weihua Kai;Yoshio Inoue
• 通讯作者: Yoshio Inoue

Fully-Biodegradable Poly(3-hydoroxybutyrate)/Poly(vinyl alcohol) Blend Films with Compositional Gradient

具有成分梯度的完全生物降解聚（3-羟基丁酸酯）/聚（乙烯醇）共混薄膜

• 发表时间: 2004
• 期刊: Macromol.Biosci. Vol.4, No.8
• 作者: Li Zhao;Katsunori Tsuchiya;Yoshio Inoue
• 通讯作者: Yoshio Inoue

Jinanchun Li: "Thermal and Mechanical Properties of Biodegradable Blends of Poly(L-lactic acid) and Lignin"Polymer International. 52,6. 949-955 (2003)

Jinanchun Li：“聚（L-乳酸）和木质素可生物降解混合物的热和机械性能”聚合物国际。

Quantitative Analysis of Compositionasl Distribution in Biodegradable Poly(ethylene oxide)/Poly(3-hydroxybutyrate) Blend Film with Compositional Gradient by FT-IR Microspectroscopy

采用 FT-IR 显微光谱法定量分析具有成分梯度的生物可降解聚环氧乙烷/聚 3-羟基丁酸酯共混膜的成分分布

• 期刊: Macromol.Chem.Phys. (印刷中)
• 作者: Bo Zhu;Jianchun Li;Yong He;Naoko Yoshie;Yoshio Inoue;Li Zhao;Li Zhao
• 通讯作者: Li Zhao