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Development of Micro Robot for Nano Operation into Bio Cell

生物细胞纳米操作微型机器人的开发

基本信息

批准号：
15360134
负责人：
AOYAMA Hisayuki
金额：
$ 4.93万
依托单位：
The University of Eelctro-Communications
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15360134/
关键词：
Nano operation Micro robot Bio cell micro flow NSOM probe UV observation piezo element 熱流動微小流量タンパク顕微鏡

项目摘要

In this research, it is the final goal to develop the micro robot with nano positioning resolution for injecting such micro glass pipette into the bio cell in order to operate the material. In the next step, it will be considered that the micro flow of such protein in the bio cell can be monitored and the micro robot with micro probe can make the nano manipulation for micro chemical reaction.In this project, the results as mentioned below were achieved ;(1)Micro robot with nano manipulation :The newly developed micro robot is composed of the piezo and electro magnet for providing nano stepping motion. And the micro tool also can be controlled to the specified potision with the accuracy of nano level.And the bio cell can be converyed and rotated around the vibrated pipette alon the micro flow.(2)Micro thermal sensng by the micro pipette coated the metal.In order to measure the temperature at the local area of bio cell, the micro pipette that is coated by the special metal such Ni and Cu to generate the micro voltage.(3)Nano machining by SPMIt was succeeded that the special thin SPM probe was developed for making femt level of machining with the help of electrical field effect between the tip and the sample. As the results of experiment, it succeeded in providing nano metal on the small target tip.

在本研究中，最终目标是开发具有纳米定位分辨率的微型机器人，将这种微型玻璃移液管注入生物细胞中，对材料进行操作。下一步，我们将考虑对这种蛋白质在生物细胞内的微流动进行监测，并利用微型探针的微型机器人对微化学反应进行纳米操作。在本项目中，取得了以下成果：(1)具有纳米操作的微型机器人：新开发的微型机器人由压电陶瓷和电磁铁组成，提供纳米步进运动。并可将微刀控制在指定位置，精度达到纳米级。并且生物细胞可以沿着微流沿振动移液管进行转换和旋转。(2)通过涂覆金属的微移液管进行微热传感。为了测量生物细胞局部区域的温度，在微移液管上涂覆Ni、Cu等特殊金属来产生微电压。(3) SPMIt纳米加工取得了成功，利用探针与样品之间的电场效应，研制出了一种特殊的SPM细探针，以达到纳米加工水平。实验结果表明，它成功地在小靶尖上提供了纳米金属。