Study of brain plasticity and functional and psychological adaptability caused by alteration of oral environment

口腔环境改变引起的脑可塑性及功能心理适应性研究

基本信息

批准号：
15390587
负责人：
WATANABE Makoto
金额：
$ 6.66万
依托单位：
TOHOKU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15390587/
关键词：
functional MRI brain plasticity oral environment oral function functional MRI

项目摘要

We evaluated brain function using functional magnetic resonance image (fMRI) to demonstrate brain activity change of mastication. fMRI acquisition protocol used in the present study has been optimised in our pilot study. 6 adult male subjects (mean age 23.2) were told to use occlusal splint for 7 days. fMRI was performed on day 1, 3, 7 of occlusal splint use and day 7 after occlusal splint removal. After fMRI acquisition, subjective sensations of every subject were recorded with "Visual Analog Scale". fMRI data were analyzed with SPM2 (Statistical Parametric Mapping 2) to determine differences of brain activity between with and without occlusal Splint (p=0.001 uncorrected, extent threshold=20voxels). On day 1 of occlusal splint use, cerebellum and left middle frontal gyrus (BA10) were more activated with occlusal splint than without it. These results showed the activation of cerebellum and frontal lobe during "motor learning". On day 3 and 7 of occlusal splint use, no difference of activity was detected in cerebellum and frontal lobe. On day 7 after occlusal splint removal, left premotor cortex was more activated with occlusal splint than without it. These findings suggest that brain neural network corresponding to new pattern of masticatory movement was constructed and maintained after occlusal splint removal. Although we analyzed association between subjective sensation score by VAS and brain activity using SPM2, no significant correlation was observed.

我们使用功能磁共振图像（fMRI）评估了大脑功能，以证明咀嚼的大脑活性变化。本研究中使用的fMRI获取方案已在我们的试点研究中得到了优化。 6名成年男性受试者（平均年龄23.2）被告知使用咬合夹板7天。在咬合夹板使用的第1、3、7、7和咬合夹板去除后第7天进行了fMRI。 fMRI获取后，以“视觉模拟量表”记录了每个受试者的主观感觉。用SPM2（统计参数映射2）分析fMRI数据，以确定与咬合夹板和没有咬合夹板之间的脑活动差异（p = 0.001未校正，范围阈值= 20伏coxels）。在使用咬合夹板的第1天，小脑和左侧正面回（BA10）被咬合夹板更激活。这些结果表明在“运动学习”期间，小脑和额叶的激活。在使用咬合夹板的第3和第7天，在小脑和额叶中未检测到活性差异。在去除咬合夹板后的第7天，左前皮层被咬合夹板比没有塞子更激活。这些发现表明，在去除咬合夹板后构建并维持了与新的咀嚼运动模式相对应的大脑神经网络。尽管我们使用SPM2分析了VAS的主观感觉评分与脑活动之间的关联，但未观察到显着的相关性。