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Research on the mechanism of generalized skin reaction caused by trichloroethylene exposure

三氯乙烯暴露引起全身皮肤反应的机制研究

基本信息

批准号：
15406026
负责人：
NASU Tamie
金额：
$ 8.51万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

After banning of chlorofluorocarbons and 1,1,1-trichloroethane, various kinds of solvents have been used as substitutes for the above degreasing agents in great demand. As a result, in the developing Asian countries where the rapid industrialization goes far beyond the development of the occupational health system, there have been epidemics of unexpected health disorders (severe skin and liver disorders due to trichloroethylene, TRI) resulting from the introduction of the alternatives. It is notable that TRI, of which the consumed amount dramatically decreased in Japan, is widely used as an alternative solvent in China and has become a cause of this new occupational disease. Especially in Guangdong Province, 208 patients (including 29 fatalities) suffered from the disorders until 2004. While TRI was mainly used as degreaser for metal parts, lens, and semiconductors in the developed countries, there have been only limited number of reports about the disorders. Thus clarifying the mechan … More ism and establishing the preventive measures are urgent issues.We have conducted international collaborative study since 2003 with Hospital for Occupational Diseases Control of Guangdong Province. We investigated TRI exposure levels of the colleague in the company, where the patients worked, by measuring personal exposure levels as well as the urinary metabolites of trichloroethylene. Many workers engaged in their work at higher TRI exposure level than the Occupational Exposure limits in Japan. Many patients with generalized skin reaction were thought to work at the higher exposure levels than the limits in Japan, judging from their urinary metabolites of trichloroethylene.As for the immunological analysis for the infection by several kinds of virus, there are many patients (14/59) with positive for anti-human herpes virus 6 (HHV6). Interestingly, no positive subjects were seen in the control group. These results suggest that reactivation of HHV6 may be induced in these patients, but the relationship to the development of these diseases are still unknown. Less

在氯氟烃和1，1，1-三氯乙烷被禁用后，各种溶剂已被用作上述溶剂的替代品，需求量很大。因此，在亚洲发展中国家，快速工业化远远超出了职业卫生系统的发展，由于采用替代品，出现了意想不到的健康疾病流行病（三氯乙烯导致的严重皮肤和肝脏疾病）。值得注意的是，TRI在日本的消费量急剧下降，在中国被广泛用作替代溶剂，并已成为这种新职业病的原因。特别是在广东省，208例患者（包括29例死亡）遭受的疾病，直到2004年。虽然TRI在发达国家主要用作金属部件、透镜和半导体的脱脂剂，但关于这些病症的报道数量有限。从而阐明了机制 ...更多信息从2003年起，我院与广东省职业病防治院开展了国际合作研究。我们通过测量个人暴露水平以及三氯乙烯的尿液代谢物，调查了患者工作公司同事的TRI暴露水平。许多工人在TRI暴露水平高于日本职业暴露限值的情况下从事工作。从尿中三氯乙烯的代谢产物判断，许多全身皮肤反应的患者被认为是在高于日本限值的暴露水平下工作的，至于几种病毒感染的免疫学分析，有许多患者（14/59）抗人疱疹病毒6（HHV 6）阳性。有趣的是，在对照组中没有看到阳性受试者。这些结果表明，在这些患者中可能诱导HHV 6的重新激活，但与这些疾病的发展的关系仍然未知。少