Research on the mechanism of generalized skin reaction caused by trichloroethylene exposure
三氯乙烯暴露引起全身皮肤反应的机制研究
基本信息
- 批准号:15406026
- 负责人:
- 金额:$ 8.51万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2003
- 资助国家:日本
- 起止时间:2003 至 2005
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
After banning of chlorofluorocarbons and 1,1,1-trichloroethane, various kinds of solvents have been used as substitutes for the above degreasing agents in great demand. As a result, in the developing Asian countries where the rapid industrialization goes far beyond the development of the occupational health system, there have been epidemics of unexpected health disorders (severe skin and liver disorders due to trichloroethylene, TRI) resulting from the introduction of the alternatives. It is notable that TRI, of which the consumed amount dramatically decreased in Japan, is widely used as an alternative solvent in China and has become a cause of this new occupational disease. Especially in Guangdong Province, 208 patients (including 29 fatalities) suffered from the disorders until 2004. While TRI was mainly used as degreaser for metal parts, lens, and semiconductors in the developed countries, there have been only limited number of reports about the disorders. Thus clarifying the mechan … More ism and establishing the preventive measures are urgent issues.We have conducted international collaborative study since 2003 with Hospital for Occupational Diseases Control of Guangdong Province. We investigated TRI exposure levels of the colleague in the company, where the patients worked, by measuring personal exposure levels as well as the urinary metabolites of trichloroethylene. Many workers engaged in their work at higher TRI exposure level than the Occupational Exposure limits in Japan. Many patients with generalized skin reaction were thought to work at the higher exposure levels than the limits in Japan, judging from their urinary metabolites of trichloroethylene.As for the immunological analysis for the infection by several kinds of virus, there are many patients (14/59) with positive for anti-human herpes virus 6 (HHV6). Interestingly, no positive subjects were seen in the control group. These results suggest that reactivation of HHV6 may be induced in these patients, but the relationship to the development of these diseases are still unknown. Less
在禁止使用氯氟烃和1,1,1-三氯乙烷后,各种溶剂被大量用于替代上述脱脂剂。因此,在快速工业化远远超过职业卫生系统发展的亚洲发展中国家,由于采用替代品,出现了意想不到的健康疾病(三氯乙烯引起的严重皮肤和肝脏疾病)的流行。值得注意的是,在日本,TRI的消费量急剧减少,而在中国,TRI被广泛用作替代溶剂,并已成为这一新型职业病的原因之一。特别是在广东省,截至2004年,有208例患者(其中29例死亡)患有这种疾病。虽然TRI在发达国家主要用作金属零件、透镜和半导体的脱脂剂,但关于这种疾病的报道数量有限。因此,明确机制、强化机制、建立防范措施是亟待解决的问题。2003年起与广东省职业病控制医院开展国际合作研究。我们通过测量个人接触水平以及尿中三氯乙烯代谢物,调查了患者所在公司同事的三氯乙烯接触水平。许多工人在比日本职业暴露限值更高的TRI暴露水平下从事工作。根据尿中三氯乙烯的代谢物判断,许多有全身皮肤反应的患者被认为在比日本的限值更高的暴露水平下工作。在多种病毒感染的免疫学分析中,抗人类疱疹病毒6 (HHV6)阳性的患者较多(14/59)。有趣的是,在对照组中没有发现阳性受试者。这些结果提示,在这些患者中可能会诱导HHV6的再激活,但与这些疾病的发展的关系尚不清楚。少
项目成果
期刊论文数量(17)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Nakajima T, Yamanosita O, Kamijima M, Kishi R, Ichihara G: "Generalized skin reactions in relation to trichloroethylene exposure : a review from the viewpoint of drug-metabolizing enzymes"J Occup Health. 45(1). 8-14 (2003)
Nakajima T、Yamanosita O、Kamijima M、Kishi R、Ichihara G:“与三氯乙烯暴露相关的全身皮肤反应:从药物代谢酶的角度进行综述”J Occup Health。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Systemic severe skin and liver disorders in workers exposed to trichloroethylene. 2. Urinary metabolites
接触三氯乙烯的工人会出现全身性严重皮肤和肝脏疾病。
- DOI:
- 发表时间:2004
- 期刊:
- 影响因子:0
- 作者:上島通浩他;Kamijima M et al.;上島通浩他;黄漢林他;上島通浩他;Huang K et al.;Kamijima M et al.
- 通讯作者:Kamijima M et al.
トリクロロエチレン作業者に発生する全身性皮膚・肝障害 第1報 : 患者発生作業状況の調査
三氯乙烯作业人员发生的全身皮肤和肝脏损伤 第1部分:患者发生地工作情况的调查
- DOI:
- 发表时间:2003
- 期刊:
- 影响因子:0
- 作者:上島通浩他;Kamijima M et al.;上島通浩他;黄漢林他;上島通浩他;Huang K et al.;Kamijima M et al.;Nakajima et al.;王 海蘭他
- 通讯作者:王 海蘭他
Systemic severe skin and liver disorders in workers exposed to trichloroethylene.
接触三氯乙烯的工人会出现全身性严重皮肤和肝脏疾病。
- DOI:
- 发表时间:2005
- 期刊:
- 影响因子:0
- 作者:上島通浩他;Kamijima M et al.
- 通讯作者:Kamijima M et al.
Generalized skin reactions in relation to trichloroethylene exposure : A review from the drug-metabolizing enzymes
与三氯乙烯暴露相关的全身皮肤反应:药物代谢酶的综述
- DOI:
- 发表时间:2003
- 期刊:
- 影响因子:0
- 作者:Nakajima T;Yamanoshita O;Kamijima M;Kishi R;Ichihara G.
- 通讯作者:Ichihara G.
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
NASU Tamie其他文献
NASU Tamie的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('NASU Tamie', 18)}}的其他基金
Elucidation of Molecular Mechanisms of Nonalcoholic Steatohepatitis Development and Prevention Caused by Adipocyte Transformation
脂肪细胞转化引起的非酒精性脂肪性肝炎发生和预防的分子机制的阐明
- 批准号:
19K10583 - 财政年份:2019
- 资助金额:
$ 8.51万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Anti-CYP2E1-induced by trichloroethylene exposure might be involved in the hypersensitivity syndrome
三氯乙烯暴露诱导的抗 CYP2E1 可能与过敏综合征有关
- 批准号:
16K15383 - 财政年份:2016
- 资助金额:
$ 8.51万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
New prevention strategies for non-alcoholic steatohepatitis - a study on the importance of blood pressure and nutritional management
非酒精性脂肪性肝炎的新预防策略——血压和营养管理重要性的研究
- 批准号:
15H04788 - 财政年份:2015
- 资助金额:
$ 8.51万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Analysis of specific protein to hypersensitivity induced by trichloroethylene
三氯乙烯致过敏反应特异性蛋白分析
- 批准号:
24659299 - 财政年份:2012
- 资助金额:
$ 8.51万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Molecular mechanism for prevention of high-fat and -cholesterol-induced fibrotic steatohepatitis and development of the non-invasive biomarker
预防高脂肪和胆固醇诱导的纤维化脂肪性肝炎的分子机制以及非侵入性生物标志物的开发
- 批准号:
23390161 - 财政年份:2011
- 资助金额:
$ 8.51万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Trichloroethylene-induced hypersensitivity may be caused by its active metabolite-protein adducts
三氯乙烯引起的过敏可能是由其活性代谢物-蛋白质加合物引起的
- 批准号:
22659123 - 财政年份:2010
- 资助金额:
$ 8.51万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Epidemiological study on environmental and genetic factor of trichlroetylene-induced hypersensitivity
三氯乙烯所致超敏反应环境及遗传因素的流行病学研究
- 批准号:
21406016 - 财政年份:2009
- 资助金额:
$ 8.51万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Study on toxic mechanism of chemical substances eluted from containers and packages and risk assessment
容器包装化学物质溶出毒性机理研究及风险评估
- 批准号:
20390171 - 财政年份:2008
- 资助金额:
$ 8.51万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Study on the environmental and individual factors of trichloroethylene-induced generalized skin disorder with hepatitis
三氯乙烯所致肝炎全身性皮肤病的环境及个体因素研究
- 批准号:
18406020 - 财政年份:2006
- 资助金额:
$ 8.51万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Adverse effects of endocrine-disrupting chemicals and the mechanism via nuclear receptor in relation to the risk assessment
内分泌干扰物的不良反应及其通过核受体的机制与风险评估的关系
- 批准号:
14370121 - 财政年份:2002
- 资助金额:
$ 8.51万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
相似海外基金
EAPSI: Ultrafine Particle Exposure Concentrations in Chinese Urban Homes
EAPSI:中国城市家庭超细颗粒物暴露浓度
- 批准号:
0914250 - 财政年份:2009
- 资助金额:
$ 8.51万 - 项目类别:
Fellowship