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Research on the mechanism of generalized skin reaction caused by trichloroethylene exposure

三氯乙烯暴露引起全身皮肤反应的机制研究

基本信息

批准号：
15406026
负责人：
NASU Tamie
金额：
$ 8.51万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

After banning of chlorofluorocarbons and 1,1,1-trichloroethane, various kinds of solvents have been used as substitutes for the above degreasing agents in great demand. As a result, in the developing Asian countries where the rapid industrialization goes far beyond the development of the occupational health system, there have been epidemics of unexpected health disorders (severe skin and liver disorders due to trichloroethylene, TRI) resulting from the introduction of the alternatives. It is notable that TRI, of which the consumed amount dramatically decreased in Japan, is widely used as an alternative solvent in China and has become a cause of this new occupational disease. Especially in Guangdong Province, 208 patients (including 29 fatalities) suffered from the disorders until 2004. While TRI was mainly used as degreaser for metal parts, lens, and semiconductors in the developed countries, there have been only limited number of reports about the disorders. Thus clarifying the mechan … More ism and establishing the preventive measures are urgent issues.We have conducted international collaborative study since 2003 with Hospital for Occupational Diseases Control of Guangdong Province. We investigated TRI exposure levels of the colleague in the company, where the patients worked, by measuring personal exposure levels as well as the urinary metabolites of trichloroethylene. Many workers engaged in their work at higher TRI exposure level than the Occupational Exposure limits in Japan. Many patients with generalized skin reaction were thought to work at the higher exposure levels than the limits in Japan, judging from their urinary metabolites of trichloroethylene.As for the immunological analysis for the infection by several kinds of virus, there are many patients (14/59) with positive for anti-human herpes virus 6 (HHV6). Interestingly, no positive subjects were seen in the control group. These results suggest that reactivation of HHV6 may be induced in these patients, but the relationship to the development of these diseases are still unknown. Less

在禁止使用氯氟烃和1,1,1-三氯乙烷后，各种溶剂被大量用于替代上述脱脂剂。因此，在快速工业化远远超过职业卫生系统发展的亚洲发展中国家，由于采用替代品，出现了意想不到的健康疾病（三氯乙烯引起的严重皮肤和肝脏疾病）的流行。值得注意的是，在日本，TRI的消费量急剧减少，而在中国，TRI被广泛用作替代溶剂，并已成为这一新型职业病的原因之一。特别是在广东省，截至2004年，有208例患者（其中29例死亡）患有这种疾病。虽然TRI在发达国家主要用作金属零件、透镜和半导体的脱脂剂，但关于这种疾病的报道数量有限。因此，明确机制、强化机制、建立防范措施是亟待解决的问题。2003年起与广东省职业病控制医院开展国际合作研究。我们通过测量个人接触水平以及尿中三氯乙烯代谢物，调查了患者所在公司同事的三氯乙烯接触水平。许多工人在比日本职业暴露限值更高的TRI暴露水平下从事工作。根据尿中三氯乙烯的代谢物判断，许多有全身皮肤反应的患者被认为在比日本的限值更高的暴露水平下工作。在多种病毒感染的免疫学分析中，抗人类疱疹病毒6 （HHV6）阳性的患者较多（14/59）。有趣的是，在对照组中没有发现阳性受试者。这些结果提示，在这些患者中可能会诱导HHV6的再激活，但与这些疾病的发展的关系尚不清楚。少