Epidemiological study on environmental and genetic factor of trichlroetylene-induced hypersensitivity

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We investigated trichloroethylene exposure levels, HLA-B genotypes, human herpes virus 6(HHV6) reactivation and cytokine levels(TNFαand IL10) in 82 patients with hypersensitivity and 137 healthy controls who worked factory using trichloroethylene. Frequencies of HLA-B* 1301 genotype were 55 patients(67%) in the patients, while only 8 persons(6%) in the control workers. Of 38 patients, 27 patients(71%) had HLA-B : 1301 genotype, and urinary TCA levels of 22 patients(81. 5%) exceeded biological exposure index of trichloroethylene. However, all control workers with HLA-B : 1301 genotype estimated to work under biological exposure index of trichloroethylene. Frequencies of patients with HHV6 reactivation(85%), elevations of plasma TNFα(57%) and IL10(85. 3%) were significantly higher in the patients group than control workers(14. 5, 14. 5 and 3. 6%, respectively).