课题基金 / 基金详情

Study on toxic mechanism of chemical substances eluted from containers and packages and risk assessment

Study on toxic mechanism of chemical substances eluted from containers and packages and risk assessment
容器包装化学物质溶出毒性机理研究及风险评估
批准号：
20390171
负责人：
NASU Tamie
金额：
$11.56万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2008
资助国家：
日本
项目状态：
已结题
起止时间：
2008 至 2010
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390171/
关键词：
スチレントリマーオクタクロロスチレンアリールハイドロカーボン受容体甲状腺ホルモングルクロン酸抱合酵素CYP1A1ダイオキシン妊娠マウスメカニズムAAhRUGT3-メチルコラントレンHepa-1c1c7luciferase活性MCF-7AhR次世代影響環境ホルモン作用薬物代謝酵素グルクロン酸転移酵素(UGT)T4T3容器・包装品リスク評価

项目摘要

项目成果

NASU Tamie的其他基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Wild-type and aromatic hydrocarbon receptor(AhR)-null male mice were orally given 0, 32 and 64. mol/kg styrene trimer or octachloroatyrene for 4 days. Unexpectedly, styrene trimer down-regulated AhR mRNA expression, and accordingly down-regulated CYP1A1 and UGT1A1 and 1A6 mRNA expressions in the liver of wild-type mice. These finding were not observed in AhR-null mice. As a result, styrene trimer increased plasma total and free T4 levels in the wild-type mice.Octachlorostyrene treatment transactivated AhR and induced CYP1A1 and UGT1A1 in the wild-type mice. However, this chemical did not influence plasma T4 lebels.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Octachlorostyrene induces cytochrome P450, UDP-glucuronosyltransferase, and sulfotransferase via the aryl hydrocarbon receptor and constitutive androstane receptor.
DOI： 10.1093/toxsci/kfp130
发表时间： 2009-09
期刊： Toxicological sciences : an official journal of the Society of Toxicology
影响因子： --
作者： [Y. Yanagiba;Yuki Ito;M. Kamijima;F. Gonzalez;T. Nakajima]
通讯作者： Y. Yanagiba;Yuki Ito;M. Kamijima;F. Gonzalez;T. Nakajima
Bisphenol A may cause testosterone reduction by adversely affecting both testis and pituitary systems similar to estradiol
DOI： 10.1016/j.toxlet.2010.02.002
发表时间： 2010-04-15
期刊： TOXICOLOGY LETTERS
影响因子： 3.5
作者： [Nakamura, Daichi, Yanagiba, Yukie, Nakajima, Tamie]
通讯作者： Nakajima, Tamie
Elucidation of Molecular Mechanisms of Nonalcoholic Steatohepatitis Development and Prevention Caused by Adipocyte Transformation
  • 批准号：
    19K10583
  • 项目类别：
    Grant-in-Aid for Scientific Research (C)
  • 资助金额：
    $2.75万
  • 财政年份：
    2019
  • 负责人：
    NASU Tamie
  • 依托单位：
    Chubu University
Anti-CYP2E1-induced by trichloroethylene exposure might be involved in the hypersensitivity syndrome
  • 批准号：
    16K15383
  • 项目类别：
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额：
    $2.25万
  • 财政年份：
    2016
  • 负责人：
    NASU Tamie
  • 依托单位：
    Chubu University
New prevention strategies for non-alcoholic steatohepatitis - a study on the importance of blood pressure and nutritional management
  • 批准号：
    15H04788
  • 项目类别：
    Grant-in-Aid for Scientific Research (B)
  • 资助金额：
    $10.4万
  • 财政年份：
    2015
  • 负责人：
    NASU Tamie
  • 依托单位：
    Chubu University
Analysis of specific protein to hypersensitivity induced by trichloroethylene
  • 批准号：
    24659299
  • 项目类别：
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额：
    $2.5万
  • 财政年份：
    2012
  • 负责人：
    NASU Tamie
  • 依托单位：
    Chubu University