Analysis of cell polarity associated molecules in prostate cancer for the application to diagnosis and treatment

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The role of cell polarity associated molecules in prostate cancer especially in hormone refractory prostate cancer has been unknown. aPKC which is a key molecule of cell polarity has the various roles for the cell maintenance such as differentiation, growth, and polarity. Thus, we investigated aPKC expression and function in prostate cancer.aPKC expression showed higher levels in human prostate cancer tissues than in paired normal prostate tissues. Moreover, aPKC expression was related to recurrence free survival time. Then, we performed the experiments using siRNA for aPKC. Prostate cancer cells transfected with siRNA reduced their growth in vitro and in vivo. IL-6, which has been known as the cytokine for prostate cancer progression, was reduced in siRNA transfected cells. These results suggest that aPKC may play a role in prostate cancer progression through IL-6 expression, and also are suggested the close relationships between aPKC cell polarity system and local Rennin Angiotensin System (RAS) in prostate cancer which we have studied and have shown previously.