Analysis of cell polarity associated molecules in prostate cancer for the application to diagnosis and treatment
前列腺癌细胞极性相关分子的分析及其在诊断和治疗中的应用
基本信息
- 批准号:17390442
- 负责人:
- 金额:$ 10.05万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2005
- 资助国家:日本
- 起止时间:2005 至 2007
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The role of cell polarity associated molecules in prostate cancer especially in hormone refractory prostate cancer has been unknown. aPKC which is a key molecule of cell polarity has the various roles for the cell maintenance such as differentiation, growth, and polarity. Thus, we investigated aPKC expression and function in prostate cancer.aPKC expression showed higher levels in human prostate cancer tissues than in paired normal prostate tissues. Moreover, aPKC expression was related to recurrence free survival time. Then, we performed the experiments using siRNA for aPKC. Prostate cancer cells transfected with siRNA reduced their growth in vitro and in vivo. IL-6, which has been known as the cytokine for prostate cancer progression, was reduced in siRNA transfected cells. These results suggest that aPKC may play a role in prostate cancer progression through IL-6 expression, and also are suggested the close relationships between aPKC cell polarity system and local Rennin Angiotensin System (RAS) in prostate cancer which we have studied and have shown previously.
细胞极性相关分子在前列腺癌尤其是激素难治性前列腺癌中的作用尚不清楚。aPKC是细胞极性的关键分子,在维持细胞分化、生长和极性等方面具有多种作用。因此,我们研究了aPKC在前列腺癌中的表达和功能。aPKC在人前列腺癌组织中的表达水平高于配对的正常前列腺组织。aPKC表达与无复发生存期有关。然后,我们使用siRNA对aPKC进行实验。用siRNA转染的前列腺癌细胞在体外和体内减少了它们的生长。IL-6,其已被称为前列腺癌进展的细胞因子,在siRNA转染的细胞中减少。这些结果表明,aPKC可能通过IL-6的表达在前列腺癌的进展中发挥作用,并且还表明我们先前研究并显示的前列腺癌中aPKC细胞极性系统与局部肾素血管紧张素系统(RAS)之间的密切关系。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Growth regulation via insulin-like growth factor binding protein-4 and -2 in association with mutant K-ras in lung epithelia.
- DOI:10.2353/ajpath.2006.051068
- 发表时间:2006-11
- 期刊:
- 影响因子:0
- 作者:Hanako Sato;T. Yazawa;Takehisa Suzuki;H. Shimoyamada;K. Okudela;Masaichi Ikeda;K. Hamada;H. Yamada‐Okabe;Masayuki Yao;Y. Kubota;Takashi Takahashi;H. Kamma;H. Kitamura
- 通讯作者:Hanako Sato;T. Yazawa;Takehisa Suzuki;H. Shimoyamada;K. Okudela;Masaichi Ikeda;K. Hamada;H. Yamada‐Okabe;Masayuki Yao;Y. Kubota;Takashi Takahashi;H. Kamma;H. Kitamura
Antiproliferative efficacy of angiotensin II receptor blockers in prostate cancer
血管紧张素 II 受体阻滞剂在前列腺癌中的抗增殖功效
- DOI:
- 发表时间:2005
- 期刊:
- 影响因子:0
- 作者:Uemura H.;Nakaiagwa N.;Ishiguro H.;Kubota Y
- 通讯作者:Kubota Y
Angiotensin II receptor blocker : possibility of antitumor agent for prostate cancer.
血管紧张素 II 受体阻滞剂:前列腺癌抗肿瘤剂的可能性。
- DOI:
- 发表时间:2006
- 期刊:
- 影响因子:0
- 作者:H Uemura;H Ishiguro;Y Kubota
- 通讯作者:Y Kubota
Regulation of prostate cancer cell growth and PSA expression byAngiotensin II receptor blocker with peroxisome proliferateor-activatedreceptor gamma ligand like action
具有过氧化物酶体增殖物激活受体γ配体样作用的血管紧张素II受体阻滞剂对前列腺癌细胞生长和PSA表达的调节
- DOI:
- 发表时间:2007
- 期刊:
- 影响因子:0
- 作者:Ishiguro H;Ishiguro Y;Kubota Y;Uemura H
- 通讯作者:Uemura H
Regulation of prostate cancer cell growth and PSA expression by angiotensin II receptor blocker with peroxisome proliferator-activated receptor gamma ligand like action
- DOI:10.1002/pros.20571
- 发表时间:2007-06-15
- 期刊:
- 影响因子:2.8
- 作者:Ishiguro, Hitoshi;Ishiguro, Yukari;Uemura, Hiroji
- 通讯作者:Uemura, Hiroji
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KUBOTA Yoshinobu其他文献
KUBOTA Yoshinobu的其他文献
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{{ truncateString('KUBOTA Yoshinobu', 18)}}的其他基金
Development of visible light inducible photocatalytic nano-particles for the diagnosis of bladder cancer
开发用于诊断膀胱癌的可见光诱导光催化纳米颗粒
- 批准号:
25670684 - 财政年份:2013
- 资助金额:
$ 10.05万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
A study of measurement in laparoscopic surgery and its reproduction on surgical simulator
腹腔镜手术测量及手术模拟器再现研究
- 批准号:
23659762 - 财政年份:2011
- 资助金额:
$ 10.05万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Analysis of the molecules of cell polarity in associated with hormone
与激素相关的细胞极性分子分析
- 批准号:
21390443 - 财政年份:2009
- 资助金额:
$ 10.05万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Analysis and detection of the molecules involving hormone refractory prostate cancer by applying Proteomics methodology
应用蛋白质组学方法分析检测激素难治性前列腺癌相关分子
- 批准号:
14370517 - 财政年份:2002
- 资助金额:
$ 10.05万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Technological study for medical application of TiO_2 photocatalysis
TiO_2光催化医学应用技术研究
- 批准号:
14050083 - 财政年份:2001
- 资助金额:
$ 10.05万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
Study of the identification of new genes inducing hormone refractory prostate cancer
激素难治性前列腺癌新基因鉴定研究
- 批准号:
11470339 - 财政年份:1999
- 资助金额:
$ 10.05万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Study of the development a new type of treatment of urogenital cancer by using surface modified fine metal particles.
利用表面改性细金属颗粒开发新型治疗泌尿生殖系统癌症的研究。
- 批准号:
10557143 - 财政年份:1998
- 资助金额:
$ 10.05万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Study of the Identification of new genes associated with development and recurrence of prostate cancer
与前列腺癌发生和复发相关的新基因的鉴定研究
- 批准号:
08457428 - 财政年份:1996
- 资助金额:
$ 10.05万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Analysis of genes involving in reactivation of prostate cancer
参与前列腺癌再激活的基因分析
- 批准号:
06454460 - 财政年份:1994
- 资助金额:
$ 10.05万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
Application of photoexcited TiO2 semicondoctor to the treatment of bladder cancer
光激发TiO2半导体在膀胱癌治疗中的应用
- 批准号:
05557071 - 财政年份:1993
- 资助金额:
$ 10.05万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research (B)
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内皮平面细胞极性通路在血流方向传感中的贡献
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