Analysis of cell polarity associated molecules in prostate cancer for the application to diagnosis and treatment
Analysis of cell polarity associated molecules in prostate cancer for the application to diagnosis and treatment
批准号:
17390442
负责人:
KUBOTA Yoshinobu
金额:
$10.05万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2007
中文摘要
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英文摘要
The role of cell polarity associated molecules in prostate cancer especially in hormone refractory prostate cancer has been unknown. aPKC which is a key molecule of cell polarity has the various roles for the cell maintenance such as differentiation, growth, and polarity. Thus, we investigated aPKC expression and function in prostate cancer.aPKC expression showed higher levels in human prostate cancer tissues than in paired normal prostate tissues. Moreover, aPKC expression was related to recurrence free survival time. Then, we performed the experiments using siRNA for aPKC. Prostate cancer cells transfected with siRNA reduced their growth in vitro and in vivo. IL-6, which has been known as the cytokine for prostate cancer progression, was reduced in siRNA transfected cells. These results suggest that aPKC may play a role in prostate cancer progression through IL-6 expression, and also are suggested the close relationships between aPKC cell polarity system and local Rennin Angiotensin System (RAS) in prostate cancer which we have studied and have shown previously.
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DOI:
10.2353/ajpath.2006.051068
发表时间:
2006-11
期刊:
The American journal of pathology
影响因子:
--
作者:
[Hanako Sato;T. Yazawa;Takehisa Suzuki;H. Shimoyamada;K. Okudela;Masaichi Ikeda;K. Hamada;H. Yamada‐Okabe;Masayuki Yao;Y. Kubota;Takashi Takahashi;H. Kamma;H. Kitamura]
通讯作者:
Hanako Sato;T. Yazawa;Takehisa Suzuki;H. Shimoyamada;K. Okudela;Masaichi Ikeda;K. Hamada;H. Yamada‐Okabe;Masayuki Yao;Y. Kubota;Takashi Takahashi;H. Kamma;H. Kitamura
Antiproliferative efficacy of angiotensin II receptor blockers in prostate cancer
血管紧张素 II 受体阻滞剂在前列腺癌中的抗增殖功效
DOI:
--
发表时间:
2005
期刊:
Current Cancer Drug Targets 5
影响因子:
--
作者:
[Uemura H., Nakaiagwa N., Ishiguro H., Kubota Y]
通讯作者:
Kubota Y
Angiotensin II receptor blocker : possibility of antitumor agent for prostate cancer.
血管紧张素 II 受体阻滞剂:前列腺癌抗肿瘤剂的可能性。
DOI:
--
发表时间:
2006
期刊:
Mini Rev Med Chem 6・7
影响因子:
--
作者:
[H Uemura, H Ishiguro, Y Kubota]
通讯作者:
Y Kubota
Regulation of prostate cancer cell growth and PSA expression byAngiotensin II receptor blocker with peroxisome proliferateor-activatedreceptor gamma ligand like action
具有过氧化物酶体增殖物激活受体γ配体样作用的血管紧张素II受体阻滞剂对前列腺癌细胞生长和PSA表达的调节
DOI:
--
发表时间:
2007
期刊:
The Prostate 67
影响因子:
--
作者:
[Ishiguro H, Ishiguro Y, Kubota Y, Uemura H]
通讯作者:
Uemura H
DOI:
10.1002/pros.20571
发表时间:
2007-06-15
期刊:
PROSTATE
影响因子:
2.8
作者:
[Ishiguro, Hitoshi, Ishiguro, Yukari, Uemura, Hiroji]
通讯作者:
Uemura, Hiroji
共 14 条
Development of visible light inducible photocatalytic nano-particles for the diagnosis of bladder cancer
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批准号:25670684
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2013
-
负责人:KUBOTA Yoshinobu
-
依托单位:
A study of measurement in laparoscopic surgery and its reproduction on surgical simulator
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批准号:23659762
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2011
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负责人:KUBOTA Yoshinobu
-
依托单位:
Analysis of the molecules of cell polarity in associated with hormone
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批准号:21390443
-
项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.4万
-
财政年份:2009
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负责人:KUBOTA Yoshinobu
-
依托单位:
Analysis and detection of the molecules involving hormone refractory prostate cancer by applying Proteomics methodology
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批准号:14370517
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.15万
-
财政年份:2002
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负责人:KUBOTA Yoshinobu
-
依托单位:
Technological study for medical application of TiO_2 photocatalysis
-
批准号:14050083
-
项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$36.54万
-
财政年份:2001
-
负责人:KUBOTA Yoshinobu
-
依托单位:
Study of the identification of new genes inducing hormone refractory prostate cancer
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批准号:11470339
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$3.46万
-
财政年份:1999
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负责人:KUBOTA Yoshinobu
-
依托单位:
Study of the development a new type of treatment of urogenital cancer by using surface modified fine metal particles.
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批准号:10557143
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$3.97万
-
财政年份:1998
-
负责人:KUBOTA Yoshinobu
-
依托单位:
Study of the Identification of new genes associated with development and recurrence of prostate cancer
-
批准号:08457428
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.22万
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财政年份:1996
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负责人:KUBOTA Yoshinobu
-
依托单位:
Analysis of genes involving in reactivation of prostate cancer
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批准号:06454460
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$2.56万
-
财政年份:1994
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负责人:KUBOTA Yoshinobu
-
依托单位:
Application of photoexcited TiO2 semicondoctor to the treatment of bladder cancer
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批准号:05557071
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$3.97万
-
财政年份:1993
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负责人:KUBOTA Yoshinobu
-
依托单位:
Analysis of the genes involved in the growth of human professor
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批准号:03454388
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$2.5万
-
财政年份:1991
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负责人:KUBOTA Yoshinobu
-
依托单位:
Development of a new cancer therapy using photoexcited semiconductor particles
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批准号:01870069
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项目类别:Grant-in-Aid for Developmental Scientific Research (B).
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资助金额:$3.39万
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财政年份:1989
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负责人:KUBOTA Yoshinobu
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依托单位:
Phosphatidylinositol turnover of cancer cell menbrane and development of new treatment of renal cell carcinoma
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批准号:61570771
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.54万
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财政年份:1986
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负责人:KUBOTA Yoshinobu
-
依托单位:
海外基金