Analysis of genes involving in reactivation of prostate cancer

The Molecular background Underlying the progression to reactivation stage of前列腺癌的反应还不清楚.多种重要基因的改变， such as tumor suppressor genes， oncogenes and steroid receptor genes in reactivated前列腺癌患者were analyzed in this study.As result， genes altered in the reactivation of human prostate cancers were found as followgen Receptor genes... point mutations，gene amplification sc-myc gene·deletionsbc1-2 gene.....。在表达中，这些分子变化的一些人曾建议在内分泌治疗后的过程中引入前列腺癌的反应和低雄激素状态。

The molecular background underlying the progression to reactivation stage of prostate cancer is not yet clear.Alterations of several important genes, such as tumor suppressor genes, oncogenes and steroid receptor genes in reactivated prostate cancers were analyzed in this study.As results, genes altered in the reactivation of human prostate cancers were found as followsAndrogen Receptor genes・・・・・・・point mutations, gene amplificationsc-myc gene ・・・・・・・・・・・・over expression, gene amplificationP53 gene ・・・・・・・・・・・・point mutations, deletionsRB gene ・・・・・・・・・・point mutations, deletionsbc1-2 gene ・・・・・・・・・・・over expressionSome of these molecular changes have ben suggested to introduce the reactivation of prostate cancer in the process of apoptosis and low androgens status after endocrine therapy.