Molecular Mechanism of Anchorage-Dependent and-Independent Proliferation

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Virtually all the cells composing solid organs of adult animals require an anchorage to the extracellular matrix and without this, arrest in G1 phase and die of apoptosis. Upon malignant transformation, these cells acquire the ability to proliferate without anchorage. This ability is generally believed to underlie their tumorigenicity. In this research project, we sought to understand the molecular mechanism controlling anchorage-dependent and-independent proliferation, which remains totally unknown, and now, the entire mechanism is largely understood. Consequently, a new, seemingly most effective target for anticancer therapy emerged.