An anti-c-Fms Antibody Inhibits Orthodontic Tooth Movement

抗 c-Fms 抗体抑制正畸牙齿移动

• 批准号: 18592242
• 负责人: KITAURA Hideki
• 金额: $ 2.49万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18592242/
• 关键词: Osteoclast; TNF-α; Orthodontic

Orthodontic force induces osteoclastogenesis in vivo. It has recently been reported that administration of an antibody against the macrophage-colony-stimulating factor(M-CSF)receptor c-Fms blocks osteoclastogenesis and bone erosion induced by tumor necrosis factor-α(TNF-α)administration. This study aimed to examine the effect of an anti-c-Fms antibody on mechanical loading-induced osteoclastogenesis and osteolysis in an orthodontic tooth movement model in mice. Using TNF receptor 1 and 2-deficient mice, we showed that orthodontic tooth movement was mediated by TNF-α. We injected anti-c-Fms antibody daily into a local site, for 12 days, during mechanical loading. The anti-c-Fms antibody significantly inhibited orthodontic tooth movement, markedly reduced the number of osteoclasts in vivo and inhibited TNF-α-induced osteoclastogenesis in vitro. These findings suggest that M-CSF plays an important role in mechanical loading-induced osteoclastogenesis and bone resorption during orthodontic tooth movement mediated by TNF-α.

正畸力在体内诱导破骨细胞生成。最近有报道称，应用抗巨噬细胞集落刺激因子受体c-fms的抗体，可阻断肿瘤坏死因子-α(Tumor Nunction Factor-α，肿瘤坏死因子-FMS)诱导的破骨细胞生成和骨侵蚀。本研究旨在观察抗c-FMS抗体对小鼠正畸牙移动模型中机械载荷诱导的破骨细胞形成和骨溶解的影响。利用肿瘤坏死因子受体1和2缺陷小鼠，我们发现正畸牙齿移动是由肿瘤坏死因子-α介导的。在机械负荷期间，我们每天将抗c-FMS抗体注射到局部部位，持续12天。抗c-fms抗体可显著抑制正畸牙移动，显著减少体内破骨细胞数，抑制肿瘤坏死因子-α诱导的体外破骨细胞生成。提示M-CSF在α介导的正畸牙移动过程中，在机械负荷诱导的破骨细胞形成和骨吸收中起重要作用。

项目成果

Dexamethsone suppresses bone formation via the osteoclast.

• DOI: 10.1007/978-0-387-72009-8_5
• 发表时间: 2007
• 期刊: Advances in experimental medicine and biology
• 作者: Hyun-Ju Kim;Haibo Zhao;H. Kitaura;Sandip Bhattacharyya;J. Brewer;L. Muglia;F. Ross;S. Teitelbaum

Treatment of a patient with metal hypersensitivity after orthodontic surgery

正畸术后金属过敏患者的治疗

• 发表时间: 2007
• 期刊: Angle Orthod 77(5)
• 作者: Jorge Zeredo;Tatsunori Shibazaki;Kyoko Sanefuji;Masako Yoshimatsu;Joseph Yozgatian;Sia Sheau Soon;Hitoshi Hotokezaka;Hideki Kitaura
• 通讯作者: Hideki Kitaura

「研究成果報告書概要(和文)」より

摘自《研究结果报告摘要（日文）》

• 发表时间: 2005
• 作者: Kawauchi;et. al.;Nishimura et al.;Dezawa et al.;Yoshizawa et al.;星野 幹雄;星野 幹雄
• 通讯作者: 星野 幹雄

An anti-c-Fms antibody inhibits orthodontic tooth movement

• DOI: 10.1177/154405910808700405
• 发表时间: 2008-04-01
• 期刊: JOURNAL OF DENTAL RESEARCH
• 影响因子: 7.6
• 作者: Kitaura, H.;Yoshimatsu, M.;Yoshida, N.
• 通讯作者: Yoshida, N.

Glucocorticoids and the osteoclast

• DOI: 10.1196/annals.1402.057
• 发表时间: 2007-01-01
• 期刊: SKELETAL BIOLOGY AND MEDICINE, PT A
• 作者: Kim, Hyun-Ju;Zhao, Haibo;Teitelbaum, Steven L.
• 通讯作者: Teitelbaum, Steven L.