Development of preventive measures against systemic diseases caused by oral biofilm

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Mechanisms of systemic diseases caused by oral biofilm were examined to develop new preventive methods against the diseases. Interaction between oral streptococci recovered from abscess lesion and salivary proteins was clarified. Human aortic endothelial cells were invaded by oral streptococci recovered from infective endocarditis and produced more inflammatory cytokines than non-invaded cells. Oral opportunistic bacteria recovered from pneumonia lesion showed capability to bind to saliva-coated endotracheal tubes and cuffs.