Selection of malaria protective sera useful for novel vaccine candidate discovery

生活在疟疾流行区的个体，反复接触疟疾寄生虫，逐渐对感染的临床表现产生免疫力。这种对临床疾病的抵抗力在一定程度上是由针对疟疾寄生虫无性血液阶段的抗体介导的。为了识别这些携带保护性抗体的个体，我们筛选了对未来疫苗候选发现有用的人类血清样本。在泰国西部流行村进行了三年的监测，我们成功地获得了无症状血清和有症状的患者血清作为阴性对照。

The individuals live in malaria endemic area who repeatedly exposed to the malaria parasite gradually develop immunity to the clinical manifestations of infection. This resistance to clinical disease is partly mediated by antibodies against the asexual blood stages of the malaria parasite. To identify such individuals harboring protective antibodies we have screened the human serum specimen useful for the future vaccine candidate discovery. After three-years surveillance in the endemic village in western Thailand, we have successfully obtained both asymptomatic sera and symptomatic patient sera as negative controls.