Selection of malaria protective sera useful for novel vaccine candidate discovery
Selection of malaria protective sera useful for novel vaccine candidate discovery
批准号:
19406009
负责人:
TSUBOI Takafumi
金额:
$10.73万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
The individuals live in malaria endemic area who repeatedly exposed to the malaria parasite gradually develop immunity to the clinical manifestations of infection. This resistance to clinical disease is partly mediated by antibodies against the asexual blood stages of the malaria parasite. To identify such individuals harboring protective antibodies we have screened the human serum specimen useful for the future vaccine candidate discovery. After three-years surveillance in the endemic village in western Thailand, we have successfully obtained both asymptomatic sera and symptomatic patient sera as negative controls.
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Transmission-blocking activity of DNA vaccine encoding Plasmodium vivax gametocyte protein Pvs230
编码间日疟原虫配子体蛋白 Pvs230 的 DNA 疫苗的传播阻断活性
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[J. Okuda, T. Ramamruthy, S. Yamasaki, Tachibana M.]
通讯作者:
Tachibana M.
Novel sporozoite antigen discoverly of Plasmodium falciparum screened using human antisera.
使用人抗血清筛选恶性疟原虫的新子孢子抗原。
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[松本昂, 山田健太郎, 高田賢蔵, 西園晃, 山崎伸二, Tsuboi T.]
通讯作者:
Tsuboi T.
Plasmodium falciparum rhoptry neck protein (PfRON2) expressed at both erythrocytic and pre-erythrocytic invasive parasites.
恶性疟原虫棒状颈部蛋白 (PfRON2) 在红细胞和红细胞前侵袭性寄生虫中表达。
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[J. Okuda, T. Ramamurthy, S. Yamasaki, Cao J.]
通讯作者:
Cao J.
Wheat germ cell-free system : A breakthrough in malaria vaccine candidate discovery
小麦胚芽无细胞系统:疟疾候选疫苗发现的突破
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Feng, G・T, Kodama・X, Chen・K, Okada・T, Honda, Iriko H, Tsuboi T, Yano K, Mudeppa DG, Ghoneim A, Han ET, Tsuboi T]
通讯作者:
Tsuboi T
Erythrocyte- Binding- Like molecule and Virulence of Plasmodium yoelii
红细胞结合样分子和约氏疟原虫的毒力
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Otsuki H, Kaneko O, Thongkukiatkul A, Tachibana M, Iriko H, Takeo S, Tsuboi T, Torii M]
通讯作者:
Torii M
共 11 条
Discovery of novel blood-stage malaria vaccine candidates based on the molecular function
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批准号:26253026
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$26.12万
-
财政年份:2014
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负责人:TSUBOI Takafumi
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依托单位:
Screening of novel malaria vaccine candidates with protective immune sera
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批准号:23406007
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.4万
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财政年份:2011
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负责人:TSUBOI Takafumi
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依托单位:
Identification of RBC receptors against malaria parasite molecules in the merozoite apical organelle
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批准号:21249028
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$30.87万
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财政年份:2009
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负责人:TSUBOI Takafumi
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依托单位:
Comprehensive screening and identification of the novel malaria transmission-blocking vaccine candidate antigens
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批准号:18390129
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.49万
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财政年份:2006
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负责人:TSUBOI Takafumi
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依托单位:
Genome-wide screening of the novel malaria transmission-blocking vaccine candidates
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批准号:16390125
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.6万
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财政年份:2004
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负责人:TSUBOI Takafumi
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依托单位:
Novel malaria transmission-blocking vaccine development using cell-free protein synthesis system
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批准号:16017273
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$9.6万
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财政年份:2004
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负责人:TSUBOI Takafumi
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依托单位:
High-throughput screening of novel malaria vaccine candidates using human immune sera
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批准号:16406009
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.45万
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财政年份:2004
-
负责人:TSUBOI Takafumi
-
依托单位:
Development of animal model for novel transmission-blocking vaccine research using gamete surface proteins of Plasmodium yoelii.
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批准号:14570215
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2002
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负责人:TSUBOI Takafumi
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依托单位:
Efficacy study of Plasmodium vivax transmission-blocking vaccine on field isolates
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批准号:12557026
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.32万
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财政年份:2000
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负责人:TSUBOI Takafumi
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依托单位:
Gene cloning of a novel merozoite rhoptry protein from Plasmodium falciparum
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批准号:11670242
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:1999
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负责人:TSUBOI Takafumi
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依托单位:
Malaria vaccine development of Plasmodium vivax, by using ookinete surface proteins as vaccine antigens
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批准号:09670261
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:1997
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负责人:TSUBOI Takafumi
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依托单位:
Plasmodial Proteins Expressed on The Surface of Infected Hepatocytes
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批准号:06807024
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1994
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负责人:TSUBOI Takafumi
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依托单位:
海外基金