Clinicopathological role of kl-6/muc1 with selectin ligand

kl-6/muc1 与选择素配体的临床病理学作用

• 批准号: 19590898
• 负责人: YOKOYAMA Akihito
• 金额: $ 2.91万
• 依托单位: Kochi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19590898/
• 关键词: MUC1ムチン; KL-6; 急性呼吸窮迫症候群; セレクチン; 汎発性血管内凝固症候群; 成人呼吸促迫症候群

KL-6/MUC1 is a sensitive biomarker for interstitial pneumonias. We found KL-6/MUC1mucins with selectin ligand (designated as SLAK). SLAK was found to be significantly elevated in ARDS patients. Furthermore, SLAK was discovered to be a sensitive, specific and independent predictor for DIC complication in ARDS. Therefore, measurement of SLAK level at diagnosis may be able to predict accurately future complications of DIC in ARDS. Early intervention with anti-DIC medication such as low-molecular-weight heparin in the patients with elevated level of SLAK may improve the prognosis of ARDS, which is currently extremely poor.

KL-6/MUC 1是间质性肺炎的敏感生物标志物。我们发现KL-6/MUC 1粘蛋白与选择素配体（命名为SLAK）结合。发现SLAK在ARDS患者中显著升高。SLAK是预测ARDS并发DIC的敏感、特异和独立的指标。因此，在诊断时检测SLAK水平可能能够准确预测ARDS患者DIC的未来并发症。对SLAK水平升高的患者早期应用低分子肝素等抗DIC药物进行干预，可改善目前预后极差的ARDS。

项目成果

Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis

• DOI: 10.1136/thx.2009.119974
• 发表时间: 2010-04-01
• 期刊: THORAX
• 影响因子: 10
• 作者: Senoo, Tadashi;Hattori, Noboru;Kohno, Nobuoki
• 通讯作者: Kohno, Nobuoki

Immunohistochemi cal localization of surfactant proteins A and D, and KL-6 in pulmonary alveolar protei nos is.

肺泡蛋白中表面活性蛋白 A 和 D 以及 KL-6 的免疫组织化学定位。

• 发表时间: 2008
• 期刊: Pathology 40
• 作者: Ohtstuki Y;Kobayashi;M;Yoshida. S;Ki shi mot-N;Kubo K;Yokoyama A;Lee G-H;Furihata;M
• 通讯作者: M

「正常構造」「好酸球性肺炎」「肺性心」「アスピリン喘息」ほか。「まんがで読み解く呼吸器疾患100」(河野修興監修、横山彰仁、服部登編)

「正常结构」、「嗜酸性粒细胞性肺炎」、「肺心病」、「阿司匹林哮喘」等。

• 发表时间: 2009
• 作者: Nakashima T;Yokoyama A;et. al.;横山彰仁;横山彰仁;横山彰仁;横山彰仁
• 通讯作者: 横山彰仁

Genetic ablation of the Bach1 gene reduces hyperoxic lung injury in mice: Role of IL-6

• DOI: 10.1016/j.freeradbiomed.2009.01.017
• 发表时间: 2009-04-15
• 期刊: FREE RADICAL BIOLOGY AND MEDICINE
• 影响因子: 7.4
• 作者: Tanimoto, Takuya;Hattori, Noboru;Kohno, Nobuoki
• 通讯作者: Kohno, Nobuoki

Productive cough is an independent risk factor for the development of COPD in former smokers

• 发表时间: 2010
• 作者: 山根 高