A clinicopathological study of BPSD (behavioral and psychological symptoms of dementia) in brains of patients with Alzheimer's disease and related neurodegenerative disease

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TAR-DNA binding protein 43 (TDP-43) is the major component of the tau-negative and ubiquitin-positive inclusions that characterize amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration(FTLD). Since TDP-43 protein was discovered, TDP-43 immunoreactivity has also been described in various neurodegenerative diseases. In AGD, there was a close relationship between grain pathology and TDP-43 immunoreactivity, and suggest that abnormal accumulation of TDP-43 may be involved in the pathological process and disease progression of AGD.