Human MHC restricted T cell generation using thymic organoid

使用胸腺类器官限制人类 MHC 的 T 细胞生成

• 批准号: 20200069
• 负责人: HAMAZAKI Yoko
• 金额: $ 20.38万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20200069/
• 关键词: T細胞分化; 胸腺; 上皮細胞; ヒトT細胞誘導; 表皮細胞

In this study, we tried to generate MHOrestricted human T cells in vltroby ccrcultureing human pre-T cells and human keratinocytes. We succeeded in forming thymic organoid; however, failed to induce functional T cells.

在本研究中，我们试图通过体外培养人前T细胞和人角质形成细胞来产生MHO限制性的人T细胞。我们成功地形成了胸腺类器官;然而，未能诱导功能性T细胞。

项目成果

Identification of claudin-expressing medullary thymic epithelial stem cells that maintain the functional medulla during life

鉴定表达密蛋白的髓质胸腺上皮干细胞，在生命过程中维持髓质功能

• 发表时间: 2012

A novel CD4+T cell population preferentially producing osteopontin steers altered immune function in senescence and malignancy

优先产生骨桥蛋白的新型 CD4 T 细胞群可改变衰老和恶性肿瘤中的免疫功能

• 发表时间: 2011
• 作者: Kyosuke Sato;Suhail Tahir;Yuji Fukushima;Yasuhiro Nakashima;Yoko Hamazaki and Nagahiro Minato
• 通讯作者: Yoko Hamazaki and Nagahiro Minato

加齢に伴い増加する新規CD4T細胞サブセット(T-sen)の同定とその意義

随年龄增长而增加的新型 CD4 T 细胞亚群 (T-sen) 的鉴定及其意义

• 发表时间: 2011
• 作者: 濱崎洋子;湊長博
• 通讯作者: 湊長博

Claudin-4 induction by E-protein activity in later stages of CD4/8 double-positive thymocytes to increase positive selection efficiency

• DOI: 10.1073/pnas.1014178108
• 发表时间: 2011-03-08
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Kawai, Yohei;Hamazaki, Yoko;Minato, Nagahiro
• 通讯作者: Minato, Nagahiro

Similar and Distinct Properties of MUPP1 and Patj, Two Homologous PDZ Domain-Containing Tight-Junction Proteins

• DOI: 10.1128/mcb.01505-08
• 发表时间: 2009-05-01
• 期刊: MOLECULAR AND CELLULAR BIOLOGY
• 影响因子: 5.3
• 作者: Adachi, Makoto;Hamazaki, Yoko;Tsukita, Shoichiro
• 通讯作者: Tsukita, Shoichiro