Neural Interface Therapy for Severe Heart Failure

我们之前报道过迷走神经电刺激通过乙酰胆碱的心脏保护作用显著提高大鼠慢性心力衰竭（CHF）后的长期生存率，而不依赖于心率减慢机制。然而，这种方法是侵入性的，其安全性在临床环境中尚不清楚。为了开发一种使用临床可用药物的无创神经界面治疗方法，我们研究了口服多奈哌齐（一种抗阿尔茨海默病的乙酰胆碱酯酶抑制剂）对小鼠容量超载CHF模型的心脏重塑和存活的慢性影响。口服多奈哌齐通过预防泵送衰竭和心脏重构提高CHF小鼠的存活率。

We previously reported that electric vagal nerve stimulation markedly improved long-term survival after chronic heart failure (CHF) in rats through cardioprotective effects of acetylcholine, independent of the hear rate-slowing mechanism. However, such an approach is invasive and its safety is unknown in clinical settings. To develop a noninvasive neural interface therapy with a clinically available drug, we examined the chronic effect of oral donepezil, an acetylcholinesterase inhibitor against Alzheimer's disease, on cardiac remodeling and survival with a murine model of volume-overloaded CHF. Oral donepezil treatment improve Oral donepezil improves survival of CHF mice through prevention of pumping failure and cardiac remodeling.