Neural Interface Therapy for Severe Heart Failure

我们以前报道过电迷走神经刺激通过乙酰胆碱的心脏保护作用显著改善慢性心力衰竭（CHF）大鼠的长期生存，独立于心率减慢机制。然而，这种方法是侵入性的，其安全性在临床环境中是未知的。为了开发一种临床可用药物的非侵入性神经界面治疗，我们研究了口服多奈哌齐（一种抗阿尔茨海默病的乙酰胆碱酯酶抑制剂）对容量超负荷CHF小鼠模型心脏重塑和生存的长期影响。口服多奈哌齐治疗通过预防泵衰竭和心脏重塑改善CHF小鼠的存活率。

We previously reported that electric vagal nerve stimulation markedly improved long-term survival after chronic heart failure (CHF) in rats through cardioprotective effects of acetylcholine, independent of the hear rate-slowing mechanism. However, such an approach is invasive and its safety is unknown in clinical settings. To develop a noninvasive neural interface therapy with a clinically available drug, we examined the chronic effect of oral donepezil, an acetylcholinesterase inhibitor against Alzheimer's disease, on cardiac remodeling and survival with a murine model of volume-overloaded CHF. Oral donepezil treatment improve Oral donepezil improves survival of CHF mice through prevention of pumping failure and cardiac remodeling.