Development of Efficient Catalytic Processes toward Functional Molecules Synthesis

新的过渡金属催化的偶联过程已经被开发出来，并已应用于生物活性化合物的简明合成。这些研究包括Ru催化的二炔的环化反应、铜催化的缺电子炔烃的氢芳基化反应、钯催化的芳基硼酸酯的烷氧羰基化反应等，并利用这些过程构建了天然产物和药物的分子框架。

Novel transition-metal-catalyzed coupling processes have been developed and they have been applied to the concise syntheses of biologically active compounds. These studies include the ruthenium-catalyzed cyclizations of diynes, the copper-catalyzed hydroarylations of electron-deficient alkynes, the palladium-catalyzed alkoxycarbonylation of arylboronates, etc. and the constructions of molecular framworks of natural products and drugs have been achieved using these processes.